By Fineline Cube 
Insilico Medicine, a global leader in generative AI‑driven drug discovery, announced a strategic partnership with Mabwell Bioscience (SHA: 688062) and Shanghai Haoyuan Chemexpress Co. Ltd. (SHA: 688131). The three companies will jointly build a next‑generation antibody‑drug conjugate (ADC) library spanning hundreds of targets, with the goal of accelerating industrialization and commercialization of innovative ADC therapeutics.
Partnership Architecture
| Component | Provider | Contribution |
|---|---|---|
| Antibody Portfolio | Mabwell | Hundreds of monoclonal & bispecific antibodies targeting oncology & autoimmunity antigens |
| ADC Platform | Mabwell | Proprietary conjugation technology and scalable manufacturing |
| AI Analysis | Insilico | Pharma.AI platform for disease‑mechanism, target‑characteristic, and toxicology modeling |
| Payload & Linker Library | Chemexpress | Extensive small‑molecule building blocks and tool compounds for ADC synthesis |
| End‑to‑End Service | All | From hit‑to‑lead screening through pre‑clinical and clinical development |
AI‑Enabled Design Pipeline
- Target Prioritization – Insilico’s AI engine screens disease pathways to rank antigens with the highest therapeutic potential.
- Payload‑Linker Innovation – AI models generate novel linker‑payload chemistries with optimized stability, release kinetics, and tumor selectivity.
- Druggability & Safety Prediction – Early‑stage simulations flag potential off‑target toxicity, shortening the molecular optimization cycle from years to months.
Strategic Impact
- Breakthrough in ADC Development – The collaboration represents a first‑of‑its‑kind integration of generative AI with traditional antibody engineering in China’s biopharma sector.
- R&D Efficiency Gains – By predicting druggability and safety during design, the alliance can reduce late‑stage attrition and accelerate time‑to‑market.
- Commercial Potential – The combined portfolio may position the partners to secure high‑value licensing deals and secure a foothold in the global ADC market.-Fineline Info & Tech