{"id":11159,"date":"2023-11-24T23:43:00","date_gmt":"2023-11-24T15:43:00","guid":{"rendered":"https:\/\/flcube.com\/?p=11159"},"modified":"2025-04-02T21:32:22","modified_gmt":"2025-04-02T13:32:22","slug":"fosun-pharmaceutical-gets-fda-green-light-for-hlx42-adc-clinical-study","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=11159","title":{"rendered":"Fosun Pharmaceutical Gets FDA Green Light for HLX42 ADC Clinical Study"},"content":{"rendered":"\n

Fosun Pharmaceutical (Group) Co., Ltd (HKG: 2196<\/a>; SHA: 600196<\/a>) has received approval from the US Food and Drug Administration (FDA) to initiate a Phase I clinical study for HLX42, an antibody drug conjugate (ADC) co-developed with Shanghai Henlius Biotech Inc. (HKG: 2696<\/a>) and Suzhou-based Medilink Therapeutics. The study targets advanced\/metastatic solid tumors.<\/p>\n\n\n\n

HLX42, a novel ADC candidate, targets the epidermal growth factor receptor (EGFR) and is conjugated with humanized IgG1 EGFR antibody molecules, novel cleavable ligands, and a TOPO I small molecule payload. Pre-clinical studies indicate that HLX42 inhibits tumor growth with good safety and was approved for Phase I in China last month.- Flcube.com<\/a><\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Fosun Pharmaceutical (Group) Co., Ltd (HKG: 2196; SHA: 600196) has received approval from the US…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[7,11],"tags":[62,159,270,893,862,892],"class_list":["post-11159","post","type-post","status-publish","format-standard","hentry","category-company","category-drug","tag-clinical-trial-approval-initiation","tag-fosun-pharmaceutical","tag-henlius-biotech","tag-hkg-2196","tag-hkg-2696","tag-sha-600196"],"yoast_head":"\nFosun Pharmaceutical Gets FDA Green Light for HLX42 ADC Clinical Study - Insight, China's Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"Fosun Pharmaceutical, along with Shanghai Henlius Biotech and Medilink Therapeutics, received FDA approval for a Phase I clinical study of HLX42, an ADC targeting EGFR in advanced\/metastatic solid tumors. 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