{"id":13263,"date":"2023-09-28T10:29:00","date_gmt":"2023-09-28T02:29:00","guid":{"rendered":"https:\/\/flcube.com\/?p=13263"},"modified":"2024-11-18T10:49:07","modified_gmt":"2024-11-18T02:49:07","slug":"elpiscience-biopharmaceuticals-initiates-phase-i-trial-for-anti-lilrb2-antibody-es009","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=13263","title":{"rendered":"Elpiscience Biopharmaceuticals Initiates Phase I Trial for Anti-LILRB2 Antibody ES009"},"content":{"rendered":"\n

Elpiscience Biopharmaceuticals, a China-based biopharmaceutical company, has announced that the first patient has been dosed in a Phase I clinical trial in Australia for its pipeline candidate, ES009. This investigational drug is an anti-LILRB2 (ILT4) monoclonal antibody developed to target cancers, marking a significant step in the company’s oncology research and development efforts.<\/p>\n\n\n\n

ES009: Targeting Immune Suppression in Cancer<\/strong>
LILRB2 is a protein expressed on the surface of myeloid cells, which plays a role in immune suppression within the tumor microenvironment (TME). ES009 is designed to bind to a unique epitope on LILRB2, blocking its interaction with multiple ligands. This mechanism reprograms myeloid cells from an anti-inflammatory phenotype to a pro-inflammatory phenotype, thereby stimulating T cells to target and attack cancer cells.<\/p>\n\n\n\n

Phase I Study Design and Objectives<\/strong>
Following a strong performance in preclinical testing, the Phase I study will assess the safety, tolerability, pharmacokinetics\/pharmacodynamics (PK\/PD), and preliminary clinical activity of ES009. This trial is crucial for understanding the drug’s behavior in human subjects and determining its potential efficacy in treating cancer patients.-Fineline Info & Tech<\/a><\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Elpiscience Biopharmaceuticals, a China-based biopharmaceutical company, has announced that the first patient has been dosed…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[7,11],"tags":[16,62,602],"class_list":["post-13263","post","type-post","status-publish","format-standard","hentry","category-company","category-drug","tag-cancer","tag-clinical-trial-approval-initiation","tag-elpiscience-biopharmaceuticals"],"yoast_head":"\nElpiscience Biopharmaceuticals Initiates Phase I Trial for Anti-LILRB2 Antibody ES009 - Insight, China's Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"Elpiscience Biopharmaceuticals, a China-based biopharmaceutical company, has announced that the first patient has been dosed in a Phase I clinical trial in Australia for its pipeline candidate, ES009. 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