{"id":13491,"date":"2023-09-22T13:16:00","date_gmt":"2023-09-22T05:16:00","guid":{"rendered":"https:\/\/flcube.com\/?p=13491"},"modified":"2024-11-19T13:21:21","modified_gmt":"2024-11-19T05:21:21","slug":"antengenes-anti-cd24-antibody-atg-031-gets-green-light-for-phase-i-study-at-md-anderson","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=13491","title":{"rendered":"Antengene’s Anti-CD24 Antibody ATG-031 Gets Green Light for Phase I Study at MD Anderson"},"content":{"rendered":"\n

Antengene Corporation Ltd (HKG: 6996<\/a>), a China-based biopharmaceutical company, has announced that the Institutional Review Board (IRB) of The University of Texas MD Anderson Cancer Center in Houston, Texas, has approved a Phase I study for its best-in-class anti-CD24 antibody, ATG-031. The clinical study, codenamed the PERFORM trial and led by MD Anderson, will involve patients with advanced solid tumors or B-cell non-Hodgkin lymphoma (B-NHL).<\/p>\n\n\n\n

ATG-031: A First-In-Class Humanized CD24 Monoclonal Antibody<\/strong>
ATG-031 is a groundbreaking humanized CD24 monoclonal antibody that targets the “don’t eat me” signal to prevent tumor immune evasion and enhance macrophage-mediated phagocytosis of cancer cells. CD24, a prominent “don’t eat me” signal, plays a significant role in tumor immune evasion by suppressing macrophage-mediated phagocytosis. Compared to CD47, another well-known “don’t eat me” target, CD24 has a more restricted distribution in normal tissue and higher expression in cancerous tissue. This selective expression allows for a wider therapeutic window and minimizes on-target-off-tumor toxicity. Unlike CD47, CD24 is not expressed on human red blood cells, further expanding the potential therapeutic window for ATG-031.<\/p>\n\n\n\n

Clinical Development and Approvals<\/strong>
ATG-031 earned its first trial approval in the US in May of this year, marking a significant step in the development of this innovative therapy. The upcoming PERFORM trial at MD Anderson will provide crucial data on the safety and efficacy of ATG-031 in patients with advanced solid tumors or B-NHL, potentially paving the way for new treatment options in oncology.<\/p>\n\n\n\n

Conclusion<\/strong>
The approval of the Phase I study for ATG-031 by MD Anderson’s IRB is a testament to Antengene’s commitment to advancing novel immunotherapies for cancer treatment. With its unique mechanism of action and potential for minimal off-tumor toxicity, ATG-031 holds promise for patients with a range of cancers.-Fineline Info & Tech<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Antengene Corporation Ltd (HKG: 6996), a China-based biopharmaceutical company, has announced that the Institutional Review…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[7,11],"tags":[136,926],"class_list":["post-13491","post","type-post","status-publish","format-standard","hentry","category-company","category-drug","tag-antengene","tag-hkg-6996"],"yoast_head":"\nAntengene's Anti-CD24 Antibody ATG-031 Gets Green Light for Phase I Study at MD Anderson - Insight, China's Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"Antengene Corporation Ltd (HKG: 6996), a China-based biopharmaceutical company, has announced that the Institutional Review Board (IRB) of The University of Texas MD Anderson Cancer Center in Houston, Texas, has approved a Phase I study for its best-in-class anti-CD24 antibody, ATG-031. 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