{"id":15891,"date":"2023-07-25T17:11:00","date_gmt":"2023-07-25T09:11:00","guid":{"rendered":"https:\/\/flcube.com\/?p=15891"},"modified":"2024-11-30T17:29:20","modified_gmt":"2024-11-30T09:29:20","slug":"gilead-sciences-halts-development-of-magrolimab-for-hr-mds-following-phase-iii-trial-results","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=15891","title":{"rendered":"Gilead Sciences Halts Development of Magrolimab for HR-MDS Following Phase III Trial Results"},"content":{"rendered":"\n<p>Gilead Sciences (<a href=\"https:\/\/www.google.com\/finance\/quote\/GILD:NASDAQ\">NASDAQ: GILD<\/a>) has decided to stop pursuing the potential first-in-class immunotherapy, magrolimab, for higher-risk myelodysplastic syndromes (HR-MDS) after obtaining disappointing efficacy data from a Phase III trial. Although the company has not yet released the results, it has confirmed that the study&#8217;s primary endpoints included complete response (CR) and overall survival (OS), with secondary endpoints focusing on duration of response, transfusion independence, progression-free survival (PFS), and time to transformation to acute myeloid leukemia (AML).<\/p>\n\n\n\n<p><strong>Consistent Safety Profile, Shift in Development Focus<\/strong><br>The firm noted that the safety profile of magrolimab was consistent with previous observations. Despite the setback in HR-MDS, the drug is still on track to enter development for several hematologic cancers and solid tumor malignancies. Additionally, ongoing studies are continuing in AML with TP53 mutations and in first-line, unfit AML patients.<a href=\"https:\/\/flcube.com\">-Fineline Info &amp; Tech<\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Gilead Sciences (NASDAQ: GILD) has decided to stop pursuing the potential first-in-class immunotherapy, magrolimab, for&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[7,11],"tags":[16,17,226,107,1025,25],"class_list":["post-15891","post","type-post","status-publish","format-standard","hentry","category-company","category-drug","tag-cancer","tag-clinical-trial-results","tag-gilead-sciences","tag-immunotherapy","tag-nasdaq-gild","tag-potential-first-in-class"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v27.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Gilead Sciences Halts Development of Magrolimab for HR-MDS Following Phase III Trial Results - Insight, China&#039;s Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"Gilead Sciences (NASDAQ: GILD) has decided to stop pursuing the potential first-in-class immunotherapy, magrolimab, for higher-risk myelodysplastic syndromes (HR-MDS) after obtaining disappointing efficacy data from a Phase III trial. Although the company has not yet released the results, it has confirmed that the study&#039;s primary endpoints included complete response (CR) and overall survival (OS), with secondary endpoints focusing on duration of response, transfusion independence, progression-free survival (PFS), and time to transformation to acute myeloid leukemia (AML).\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/flcube.com\/?p=15891\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gilead Sciences Halts Development of Magrolimab for HR-MDS Following Phase III Trial Results\" \/>\n<meta property=\"og:description\" content=\"Navigate the complexities of China\u2019s pharmaceutical industry with precision and clarity. 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