{"id":16155,"date":"2023-07-14T20:29:00","date_gmt":"2023-07-14T12:29:00","guid":{"rendered":"https:\/\/flcube.com\/?p=16155"},"modified":"2024-12-01T20:33:08","modified_gmt":"2024-12-01T12:33:08","slug":"innocare-pharma-and-arrivent-biopharma-partner-on-shp2-inhibitor-and-egfr-inhibitor-combination","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=16155","title":{"rendered":"InnoCare Pharma and ArriVent Biopharma Partner on SHP2 Inhibitor and EGFR Inhibitor Combination"},"content":{"rendered":"\n

China-based InnoCare Pharma (HKG: 9969<\/a>; SHA: 688428<\/a>) has announced a clinical development collaboration with US-based ArriVent Biopharma Inc. The partnership aims to evaluate the combination of InnoCare\u2019s novel SHP2 allosteric inhibitor, ICP-189, with ArriVent\u2019s furmonertinib, a highly brain-penetrant and broadly active mutation-selective EGFR inhibitor.<\/p>\n\n\n\n

Combining ICP-189 and Furmonertinib for Solid Tumor Treatments<\/strong>
ICP-189 is a potent and selective oral allosteric inhibitor of SHP2, developed by InnoCare for the treatment of solid tumors. It can be used as a single agent and\/or in combination with other antitumor agents. In a dose escalation study, ICP-189 demonstrated favorable pharmacokinetics, a long half-life, and a favorable safety and tolerability profile.<\/p>\n\n\n\n

Furmonertinib’s Background and Global Studies<\/strong>
Furmonertinib was originally discovered by Shanghai-based Allist Pharmaceuticals Inc., (688578.SH) and licensed to ArriVent for ex-China development in a July 2021 deal valued at up to USD 800 million. ArriVent is conducting global studies for the molecule as a treatment for advanced or metastatic non-small cell lung cancer (NSCLC) with EGFR or HER2 mutations, including exon 20 insertion mutations. Allist secured a first approval for furmonertinib in China in March 2021 as a first-line treatment for locally advanced or metastatic NSCLC with EGFR exon 19 deletion (19DEL) or exon 21 (L858R) substitution mutations.-Fineline Info & Tech<\/a><\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

China-based InnoCare Pharma (HKG: 9969; SHA: 688428) has announced a clinical development collaboration with US-based…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[7,10],"tags":[16,29,919,327,920],"class_list":["post-16155","post","type-post","status-publish","format-standard","hentry","category-company","category-deals","tag-cancer","tag-combination-therapy","tag-hkg-9969","tag-innocare-pharma","tag-sha-688428"],"yoast_head":"\nInnoCare Pharma and ArriVent Biopharma Partner on SHP2 Inhibitor and EGFR Inhibitor Combination - Insight, China's Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"China-based InnoCare Pharma (HKG: 9969; SHA: 688428) has announced a clinical development collaboration with US-based ArriVent Biopharma Inc. 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