{"id":17432,"date":"2024-12-10T17:20:03","date_gmt":"2024-12-10T09:20:03","guid":{"rendered":"https:\/\/flcube.com\/?p=17432"},"modified":"2024-12-10T17:20:06","modified_gmt":"2024-12-10T09:20:06","slug":"dizal-pharmaceutical-unveils-promising-data-on-dzd8586-for-b-nhl-at-ash-annual-meeting","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=17432","title":{"rendered":"Dizal Pharmaceutical Unveils Promising Data on DZD8586 for B-NHL at ASH Annual Meeting"},"content":{"rendered":"\n

China-based Dizal Pharmaceutical Co., Ltd (SHA: 688192<\/a>) has presented new data from a pooled safety and efficacy analysis of DZD8586, a non-covalent blood-brain barrier (BBB) penetrant dual inhibitor targeting LYN and BTK, in patients with B-cell non-Hodgkin lymphoma (B-NHL) at the 66th American Society of Hematology (ASH) Annual Meeting.<\/p>\n\n\n\n

Clinical Study Overview<\/strong>
The analysis compiled data from ongoing Phase I\/II clinical studies assessing DZD8586 in B-NHL patients who had either progressed after or were intolerant to previous systemic therapies. In the subgroup of chronic lymphocytic leukemia (CLL) \/ small lymphocytic lymphoma (SLL), the overall response rate (ORR) was reported at 57.9% for patients receiving doses of 50 mg or more.<\/p>\n\n\n\n

Efficacy Against Resistance Mutations<\/strong>
Tumor responses were noted in patients previously treated with both covalent and non-covalent BTK inhibitors (BTKi) and Bcl-2 inhibitors. Notably, tumor responses were observed in patients harboring classic BTK resistance mutations (C481X) as well as \u201cdead\u201d mutations. Preliminary anti-tumor activity was also recorded in patients pre-treated with pirtobrutinib, specifically those with the T474I mutation.<\/p>\n\n\n\n

Conclusion<\/strong>
Dizal Pharmaceutical’s DZD8586 is showing promise in treating challenging cases of B-NHL, particularly in patients with resistance to existing therapies. The findings presented at the ASH Annual Meeting underscore the potential of this innovative dual inhibitor in enhancing treatment options for B-cell malignancies.-Fineline Info & Tech<\/a><\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

China-based Dizal Pharmaceutical Co., Ltd (SHA: 688192) has presented new data from a pooled safety…<\/p>\n","protected":false},"author":1,"featured_media":17434,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[7,11],"tags":[106,16,17,191,981],"class_list":["post-17432","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-company","category-drug","tag-academic-conference","tag-cancer","tag-clinical-trial-results","tag-dizal-pharmaceutical","tag-sha-688192"],"yoast_head":"\nDizal Pharmaceutical Unveils Promising Data on DZD8586 for B-NHL at ASH Annual Meeting - Insight, China's Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"China-based Dizal Pharmaceutical Co., Ltd (SHA: 688192) has presented new data from a pooled safety and efficacy analysis of DZD8586, a non-covalent blood-brain barrier (BBB) penetrant dual inhibitor targeting LYN and BTK, in patients with B-cell non-Hodgkin lymphoma (B-NHL) at the 66th American Society of Hematology (ASH) Annual Meeting.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/flcube.com\/?p=17432\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dizal Pharmaceutical Unveils Promising Data on DZD8586 for B-NHL at ASH Annual Meeting\" \/>\n<meta property=\"og:description\" content=\"Navigate the complexities of China\u2019s pharmaceutical industry with precision and clarity. 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