{"id":17804,"date":"2023-06-16T10:50:00","date_gmt":"2023-06-16T02:50:00","guid":{"rendered":"https:\/\/flcube.com\/?p=17804"},"modified":"2024-12-13T10:58:16","modified_gmt":"2024-12-13T02:58:16","slug":"fosun-pharma-initiates-phase-ii-study-of-hlx26-and-serplulimab-combo-for-metastatic-crc","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=17804","title":{"rendered":"Fosun Pharma Initiates Phase II Study of HLX26 and Serplulimab Combo for Metastatic CRC"},"content":{"rendered":"\n<p>Shanghai Fosun Pharmaceutical (Group) Co., Ltd (SHA: 600196, HKG: 2196) has announced the initiation of a Phase II clinical study in China for HLX26, an in-house developed lymphocyte activation gene 3 (LAG-3, aka CD233) inhibitor, in combination with its programmed-death 1 (PD-1) inhibitor HaiSiZhuang (serplulimab) for the treatment of metastatic colorectal cancer (mCRC). This study focuses on the regimen&#8217;s use as a fourth-line treatment option for patients.<\/p>\n\n\n\n<p><strong>Understanding the Mechanism of Action of LAG-3 Inhibition<\/strong><br>LAG-3 is a complex-binding immunoassay receptor that activates effector T cell activity while inhibiting T reg activity, sharing a similar mechanism of action to that of PD-1 inhibition. Primarily expressed on activated T cells and some NK cells, LAG-3 has a negative regulatory effect on T cell proliferation, activation, and homeostasis. By inhibiting LAG-3, it is possible to reactivate T cells and restore their ability to target and kill tumor cells.<\/p>\n\n\n\n<p><strong>Serplulimab&#8217;s Global Clinical Studies and Approvals<\/strong><br>Serplulimab has been approved in China for the treatment of unresectable or metastatic microsatellite highly unstable (MSI-H) solid tumors that have failed standard therapy, squamous non-small cell lung cancer (sqNSCLC), and extensive stage small cell lung cancer (ES-SCLC). The drug is a central component in multiple global clinical studies, including eleven different combination therapies. A market filing for serplulimab combined with cisplatin plus fluorouracil (5-FU) for first-line locally advanced\/recurrent or metastatic esophageal squamous cell carcinoma (ESCC) has been accepted for review by the NMPA.<\/p>\n\n\n\n<p><strong>Ongoing Studies for HLX26 in Solid Tumors and Lymphoma<\/strong><br>HLX26 is currently undergoing a Phase I study in solid tumors and lymphoma, as well as a Phase I study in combination with serplulimab in solid tumors. Additionally, the HLX26\/serplulimab combination has previously been cleared for a Phase II study in NSCLC in China, indicating the potential synergistic effects of this dual immunotherapy approach in cancer treatment.<a href=\"https:\/\/flcube.com\">-Fineline Info &amp; Tech<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Shanghai Fosun Pharmaceutical (Group) Co., Ltd (SHA: 600196, HKG: 2196) has announced the initiation of&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[7,11],"tags":[16,62,29,159,893,18,892],"class_list":["post-17804","post","type-post","status-publish","format-standard","hentry","category-company","category-drug","tag-cancer","tag-clinical-trial-approval-initiation","tag-combination-therapy","tag-fosun-pharmaceutical","tag-hkg-2196","tag-pd-1-l1","tag-sha-600196"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v27.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Fosun Pharma Initiates Phase II Study of HLX26 and Serplulimab Combo for Metastatic CRC - Insight, China&#039;s Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"Shanghai Fosun Pharmaceutical (Group) Co., Ltd (SHA: 600196, HKG: 2196) has announced the initiation of a Phase II clinical study in China for HLX26, an in-house developed lymphocyte activation gene 3 (LAG-3, aka CD233) inhibitor, in combination with its programmed-death 1 (PD-1) inhibitor HaiSiZhuang (serplulimab) for the treatment of metastatic colorectal cancer (mCRC). 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