{"id":17894,"date":"2023-06-15T02:02:00","date_gmt":"2023-06-14T18:02:00","guid":{"rendered":"https:\/\/flcube.com\/?p=17894"},"modified":"2025-01-06T18:16:12","modified_gmt":"2025-01-06T10:16:12","slug":"abbvie-inc-files-lawsuit-against-beigene-over-btk-inhibitor-brukinsa","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=17894","title":{"rendered":"AbbVie Inc. Files Lawsuit Against BeiGene Over BTK Inhibitor Brukinsa"},"content":{"rendered":"\n

US-based AbbVie Inc., (NYSE: ABBV<\/a>), the company behind the first-in-class Bruton\u2019s tyrosine kinase (BTK) inhibitor Imbruvica (ibrutinib), has taken legal action against BeiGene\u2019s (NASDAQ: BGNE<\/a>) BTK inhibitor Brukinsa (zanubrutinib). The lawsuit was filed by AbbVie subsidiary Pharmacyclics in the Delaware District Court on the day it was awarded a new patent for Imbruvica, US Patent No. 11,672,803 (the \u2019803 Patent), which covers the use of an oral BTK inhibitor for treating chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL\/SLL). No official announcements have been made by either company regarding the lawsuit, and BeiGene\u2019s Hong Kong share price fell by 12.43% following the news. <\/p>\n\n\n\n

Imbruvica’s History and Market Performance<\/strong>
Imbruvica, originally discovered by Celera Genomics, was acquired by Pharmacyclics in a 2006 deal. The drug received its first approval to treat mantle cell lymphoma (MCL) in 2013 and has since added 11 other indications, including CLL in 2014 and CLL\/SLL in 2016. Imbruvica’s remarkable performance in treating blood cancers, particularly CLL, led AbbVie to invest USD 21 billion in 2016 to acquire a controlling stake in Pharmacyclics. By 2020, Imbruvica generated USD 6.6 billion in sales, making it the fourth top-selling cancer drug that year, with forecasts predicting USD 10 billion in annual revenues by 2024.<\/p>\n\n\n\n

Competition in the BTK Inhibitor Space<\/strong>
AstraZeneca entered the BTK market with Calquence (acalabrutinib) in 2017, followed by BeiGene\u2019s Brukinsa, which was first approved in the US in November 2019 for MCL and later for CLL\/SLL. Both drugs aim to provide more targeted BTK inhibition compared to Imbruvica. BeiGene conducted a head-to-head clinical trial comparing Brukinsa with Imbruvica in CLL, with final data in December 2022 showing significant improvements in progression-free survival and reduced toxicity for Brukinsa. This has led to an increasing preference for Calquence and Brukinsa over Imbruvica among US physicians. In 2022, AstraZeneca\u2019s Calquence reached over USD 2 billion in sales, while Brukinsa generated USD 564.7 million, contrasting with a 21% year-on-year decline in AbbVie’s Imbruvica sales to USD 3.4 billion.<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

US-based AbbVie Inc., (NYSE: ABBV), the company behind the first-in-class Bruton\u2019s tyrosine kinase (BTK) inhibitor…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[7,61],"tags":[234,185,2092,16,20,81,846,3046,853,25],"class_list":["post-17894","post","type-post","status-publish","format-standard","hentry","category-company","category-legal-ip","tag-abbvie","tag-beigene","tag-beone-medicines","tag-cancer","tag-finance","tag-genomics-ngs","tag-nasdaq-bgne","tag-nasdaq-onc","tag-nyse-abbv","tag-potential-first-in-class"],"yoast_head":"\nAbbVie Inc. 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No official announcements have been made by either company regarding the lawsuit, and BeiGene\u2019s Hong Kong share price fell by 12.43% following the news.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/flcube.com\/?p=17894\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"AbbVie Inc. Files Lawsuit Against BeiGene Over BTK Inhibitor Brukinsa\" \/>\n<meta property=\"og:description\" content=\"Navigate the complexities of China\u2019s pharmaceutical industry with precision and clarity. FLCUBE delivers reliable data, news, and intelligence to broaden your horizons and sharpen your decision-making. 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