{"id":19324,"date":"2023-04-23T16:59:00","date_gmt":"2023-04-23T08:59:00","guid":{"rendered":"https:\/\/flcube.com\/?p=19324"},"modified":"2024-12-22T17:03:46","modified_gmt":"2024-12-22T09:03:46","slug":"genscript-biotechs-subsidiary-legend-biotech-announces-positive-car-t-therapy-results","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=19324","title":{"rendered":"GenScript Biotech’s Subsidiary Legend Biotech Announces Positive CAR-T Therapy Results"},"content":{"rendered":"\n

China-based Contract Research Organization (CRO) GenScript Biotech Corporation (HKG: 1548<\/a>) has announced that its subsidiary, Legend Biotech Corporation (NASDAQ: LEGN<\/a>), has filed a 6-K with the US Securities and Exchange Commission and published clinical studies with the European Hematology Association (EHA) regarding its chimeric antigen receptor (CAR)-T therapies. The release confirms the strength of Carvykti in earlier treatment stages for multiple myeloma (MM), as reported by Fineline Info & Tech<\/a>.<\/p>\n\n\n\n

Phase III CARTITUDE-4 Study Results<\/strong>
The first Phase III results of the CARTITUDE-4 study compared Carvykti (ciltacabtagene autoleucel) with the standard of care (SOC) in recurrent and lenalidomide refractory multiple myeloma. The conclusion was that a single cilta-cel infusion significantly improves the progression-free survival (PFS) of refractory lenalidomide patients who have previously received line 1-3 treatment, with a good benefit\/risk ratio. The 74% reduction in progression\/death risk, along with a high proportion of complete remission (CR) and extremely low minimal residual disease (MRD) negative rates, highlight cilta-cel’s potential as a key treatment for patients with multiple myeloma after a single recurrence.<\/p>\n\n\n\n

CARTITUDE-1 Final Results<\/strong>
The final results of the Ib\/II Study for Carvykti in recurrent or refractory multiple myeloma after multiple treatments showed that RR\/MM patients who have undergone multi-line treatment observed a median PFS longer than previously reported treatment methods after receiving a single infusion of cilta-cel. Reaching CR and\/or sustained negative MRD is associated with prolonged PFS. Patients will continue to be followed up on safety and survival in the 15-year CARTITUDE-CONTINUE long-term study (NCT05201781; MMY4002).<\/p>\n\n\n\n

LEGEND-2 Study: Long-term Remission and Survival<\/strong>
The LEGEND-2 study with a follow-up of at least five years showed that RR\/MM patients who received multi-line treatment with LCAR-B38M CAR-T had a median overall survival of 55.8 months, and 18% of patients were asymptomatic. Five years of follow-up data indicate that patients who have undergone less frontline treatment or are in good functional condition may benefit more from LCAR-B38M CAR-T cell therapy and may be cured.-Fineline Info & Tech<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

China-based Contract Research Organization (CRO) GenScript Biotech Corporation (HKG: 1548) has announced that its subsidiary,…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[7,11],"tags":[21,77,17,521,872,112],"class_list":["post-19324","post","type-post","status-publish","format-standard","hentry","category-company","category-drug","tag-car-t","tag-cell-therapy","tag-clinical-trial-results","tag-genscript-biotech","tag-hkg-1548","tag-legend-biotech"],"yoast_head":"\nGenScript Biotech's Subsidiary Legend Biotech Announces Positive CAR-T Therapy Results - Insight, China's Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"China-based Contract Research Organization (CRO) GenScript Biotech Corporation (HKG: 1548) has announced that its subsidiary, Legend Biotech Corporation (NASDAQ: LEGN), has filed a 6-K with the US Securities and Exchange Commission and published clinical studies with the European Hematology Association (EHA) regarding its chimeric antigen receptor (CAR)-T therapies. 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