{"id":19331,"date":"2023-04-23T17:11:00","date_gmt":"2023-04-23T09:11:00","guid":{"rendered":"https:\/\/flcube.com\/?p=19331"},"modified":"2024-12-22T17:14:42","modified_gmt":"2024-12-22T09:14:42","slug":"neurodawn-pharmaceuticals-y-1-receives-nmpa-approval-for-primary-intracranial-tumor-treatment","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=19331","title":{"rendered":"Neurodawn Pharmaceutical&#8217;s Y-1 Receives NMPA Approval for Primary Intracranial Tumor Treatment"},"content":{"rendered":"\n<p>Nanjing-based Neurodawn Pharmaceutical Co., Ltd has announced that its Category 1 drug, injectable Y-1, has obtained clinical trial approval from the National Medical Products Administration (NMPA) for the treatment of primary intracranial malignant tumors.<\/p>\n\n\n\n<p><strong>TRPML1 Inhibitor&#8217;s Non-Clinical Study Results<\/strong><br>Non-clinical studies have demonstrated that the TRPML1 inhibitor, Y-1, can effectively inhibit the proliferation of both central nervous system (CNS) and non-CNS tumor cells. It achieves this by blocking the cell cycle at the G0\/G1 phase and inducing novel forms of tumor cell death, characterized by the induction of vacuolization phenotype in tumor cells. These findings suggest that Y-1 may offer a new approach to treating various types of cancer.<\/p>\n\n\n\n<p><strong>Pre-Clinical Penetration and Efficacy of Y-1<\/strong><br>Pre-clinical studies have shown that Y-1 can efficiently penetrate the blood-brain barrier (BBB), a critical factor for drugs targeting brain tumors, to reach and inhibit the growth of brain solid tumors. The drug has been effective against both temozolomide (TMZ)-sensitive and TMZ-insensitive brain gliomas, prolonging the survival period of mice with brain carcinoma in situ. Additionally, when used in combination with TMZ, Y-1 has been shown to enhance the efficacy of chemotherapy, indicating its potential as a valuable adjunct in cancer treatment regimens.<a href=\"https:\/\/flcube.com\">-Fineline Info &amp; Tech<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nanjing-based Neurodawn Pharmaceutical Co., Ltd has announced that its Category 1 drug, injectable Y-1, has&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[7,11],"tags":[16,62,1908],"class_list":["post-19331","post","type-post","status-publish","format-standard","hentry","category-company","category-drug","tag-cancer","tag-clinical-trial-approval-initiation","tag-neurodawn-pharmaceutical"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v27.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Neurodawn Pharmaceutical&#039;s Y-1 Receives NMPA Approval for Primary Intracranial Tumor Treatment - Insight, China&#039;s Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"Nanjing-based Neurodawn Pharmaceutical Co., Ltd has announced that its Category 1 drug, injectable Y-1, has obtained clinical trial approval from the National Medical Products Administration (NMPA) for the treatment of primary intracranial malignant tumors.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/flcube.com\/?p=19331\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Neurodawn Pharmaceutical&#039;s Y-1 Receives NMPA Approval for Primary Intracranial Tumor Treatment\" \/>\n<meta property=\"og:description\" content=\"Navigate the complexities of China\u2019s pharmaceutical industry with precision and clarity. 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