{"id":19371,"date":"2023-04-21T22:50:00","date_gmt":"2023-04-21T14:50:00","guid":{"rendered":"https:\/\/flcube.com\/?p=19371"},"modified":"2024-12-22T22:54:34","modified_gmt":"2024-12-22T14:54:34","slug":"aacr-2023-highlights-car-t-therapies-and-monoclonal-antibody-combinations-in-cancer-research","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=19371","title":{"rendered":"AACR 2023 Highlights: CAR-T Therapies and Monoclonal Antibody Combinations in Cancer Research"},"content":{"rendered":"\n

The 2023 edition of the American Association for Cancer Research (AACR) annual meeting has concluded, highlighting the latest trends in clinical cancer research. The event featured a range of CAR-T cell therapies under development, including Allogene Therapeutics’ (NASDAQ: ALLO) CD70-targeting allogeneic treatment ALLO-316, as well as anti-CD19\/CD20 and anti-TACI\/BCMA bispecific versions presented by the University of California and Elpis Biopharmaceuticals, respectively.<\/p>\n\n\n\n

Monoclonal Antibody Combinations Take Center Stage<\/strong>
Several monoclonal antibody (mAb) combinations were showcased at the event. Notable mentions include Roche’s (SWX: RO) PD-L1-targeting Tecentriq (atezolizumab) combined with anti-VEGF Avastin (bevacizumab), Novartis’ (NYSE: NVS) BAFF blocker ianalumab paired with BTK inhibitor ibrutinib, Sanofi’s (NASDAQ: SNY) anti-PD-1 Libtayo (cemiplimab) combined with BioNTech’s (NASDAQ: BNTX) cytokines mRNA cocktail SAR441000, and BeiGene’s (Nasdaq: BGNE) PD-1-targeting tislelizumab plus chemotherapy.<\/p>\n\n\n\n

Merck’s Keytruda and Other Promising Combinations<\/strong>
Merck, Sharp & Dohme’s (MSD; NYSE: MRK) blockbuster anti-PD-1 drug Keytruda (pembrolizumab) was in the spotlight, being paired with Moderna’s (NASDAQ: MRNA) cancer vaccine mRNA-4157, MiNA Therapeutics’ CEBPA upregulator MTL-CEBPA, MSD\u2019s own anti-TIGIT vibostolimab, oncolytic virus gebasaxturev, and chemotherapy.<\/p>\n\n\n\n

Cancer Vaccines and Bispecific Antibodies in Clinical Stages<\/strong>
Clinical-stage cancer vaccines featured at the event include Johns Hopkins University’s mutant KRAS (mKRAS) peptide vaccine, Evaxion Biotech’s (NASDAQ: EVAX) personalized DNA vaccine EVX-02, and Transgene’s (EPA: TNG) personalized antigenic vaccine TG4050. The list of bispecific antibodies (BsAbs) displayed includes Merus’s (NASDAQ: MRUS) anti-EGFR\/LGR5 petosemtamab, Regeneron Pharmaceuticals’s (NASDAQ: REGN) anti-BCMA\/CD3 REGN5459, and Affimed’s (NASDAQ: AFMD) anti-CD16A\/CD30 AFM13.<\/p>\n\n\n\n

Emerging Drug Classes and Targets<\/strong>
The proteolysis-targeting chimera (PROTAC) drug class was featured with Taiwan Industrial Technology Research Institute\u2019s truncated androgen receptor- (AR) targeting ITRI-148. Additionally, the yes-associated protein (YAP)\/transcriptional enhancer activator domain (TEAD) was identified as a promising drug target for future cancer treatments.-Fineline Info & Tech<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

The 2023 edition of the American Association for Cancer Research (AACR) annual meeting has concluded,…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[11,6],"tags":[16,21,107,28,18,70,12],"class_list":["post-19371","post","type-post","status-publish","format-standard","hentry","category-drug","category-rd","tag-cancer","tag-car-t","tag-immunotherapy","tag-multi-specific-antibodies","tag-pd-1-l1","tag-tpd","tag-vaccine"],"yoast_head":"\nAACR 2023 Highlights: CAR-T Therapies and Monoclonal Antibody Combinations in Cancer Research - Insight, China's Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"The 2023 edition of the American Association for Cancer Research (AACR) annual meeting has concluded, highlighting the latest trends in clinical cancer research. 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