{"id":21750,"date":"2023-02-24T23:10:00","date_gmt":"2023-02-24T15:10:00","guid":{"rendered":"https:\/\/flcube.com\/?p=21750"},"modified":"2025-01-16T23:13:59","modified_gmt":"2025-01-16T15:13:59","slug":"innocare-and-keymed-announce-first-dosing-of-icp-b05-clinical-study","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=21750","title":{"rendered":"InnoCare and Keymed Announce First Dosing of ICP-B05 Clinical Study"},"content":{"rendered":"\n

China-based firms InnoCare Pharma (HKG: 9969<\/a>, SHA: 688428<\/a>) and Keymed Biosciences (HKG: 2162<\/a>) have jointly announced the first subject dosing of a clinical study for ICP-B05 (CM369), an anti-CC chemokine receptor 8 (CCR8) monoclonal antibody (mAb) developed by their joint venture, Tiannuojiancheng Pharma. This marks a significant milestone in the development of innovative cancer therapies.<\/p>\n\n\n\n

ICP-B05: First-in-Class Drug Development<\/strong>
ICP-B05 is a potential first-in-class drug co-developed by InnoCare and Keymed, designed to be used as a monotherapy or in combination with other therapies for the treatment of various cancers. The drug selectively depletes Tregs (regulatory T cells) in the tumor microenvironment, offering a more specific approach than other immunotherapies. By binding to CCR8 on Tregs, CM369 eradicates immunosuppressive Tregs through antibody-dependent cellular cytotoxicity (ADCC), thereby augmenting anti-tumor immunity in the tumor microenvironment (TME) while preserving peripheral homeostasis. Notably, there are no CCR8-targeted drugs currently available in the world.<\/p>\n\n\n\n

Clinical Study and Therapeutic Potential<\/strong>
The initiation of the clinical study for ICP-B05 is a crucial step in evaluating the safety and efficacy of this novel therapy. The study aims to assess the drug’s performance in treating various cancers, with the potential to significantly improve patient outcomes. The unique mechanism of action of ICP-B05, targeting CCR8 on Tregs, positions it as a promising candidate in the field of immuno-oncology.<\/p>\n\n\n\n

Strategic Implications<\/strong>
The joint development of ICP-B05 by InnoCare Pharma and Keymed Biosciences highlights the collaborative efforts of these two leading biopharmaceutical companies. By leveraging their combined expertise and resources, the companies aim to accelerate the development and commercialization of this innovative therapy. The successful development of ICP-B05 could not only address significant unmet medical needs in cancer treatment but also enhance the global market presence of both InnoCare and Keymed.-Fineline Info & Tech<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

China-based firms InnoCare Pharma (HKG: 9969, SHA: 688428) and Keymed Biosciences (HKG: 2162) have jointly…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[7,11],"tags":[16,62,974,919,327,179,920],"class_list":["post-21750","post","type-post","status-publish","format-standard","hentry","category-company","category-drug","tag-cancer","tag-clinical-trial-approval-initiation","tag-hkg-2162","tag-hkg-9969","tag-innocare-pharma","tag-keymed-biosciences","tag-sha-688428"],"yoast_head":"\nInnoCare and Keymed Announce First Dosing of ICP-B05 Clinical Study - Insight, China's Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"China-based firms InnoCare Pharma (HKG: 9969, SHA: 688428) and Keymed Biosciences (HKG: 2162) have jointly announced the first subject dosing of a clinical study for ICP-B05 (CM369), an anti-CC chemokine receptor 8 (CCR8) monoclonal antibody (mAb) developed by their joint venture, Tiannuojiancheng Pharma. 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