{"id":23630,"date":"2022-12-13T13:24:00","date_gmt":"2022-12-13T05:24:00","guid":{"rendered":"https:\/\/flcube.com\/?p=23630"},"modified":"2025-01-28T13:27:14","modified_gmt":"2025-01-28T05:27:14","slug":"jw-therapeutics-presents-carteyva-data-at-ash-annual-meeting","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=23630","title":{"rendered":"JW Therapeutics Presents Carteyva Data at ASH Annual Meeting"},"content":{"rendered":"\n

China-based JW Therapeutics (HKG: 2126<\/a>) presented the latest clinical data on Carteyva (relmacabtagene autoleucel injection) in Chinese adults with relapsed\/refractory follicular lymphoma (r\/r FL) and relapsed\/refractory mantle cell lymphoma (r\/r MCL) at the 64th American Society of Hematology (ASH) annual meeting.<\/p>\n\n\n\n

Efficacy and Safety in Relapsed\/Refractory Follicular Lymphoma<\/strong>
In the pivotal phase II RELIANCE study, patients with histologically confirmed grade 1, 2, or 3a FL with r\/r disease were included. Eligible patients were randomized to receive relma-cel at the dose level of 100\u00d7106 or 150\u00d7106 CAR+ T cells, following lymphodepletion chemotherapy. At the data cut-off (Dec 17, 2021), based on 28 patients with 11.7 months of median follow-up, relma-cel demonstrated remarkable clinical responses achieving high rates of complete response rate (CRR) and overall response rate (ORR) (6 months ORR and CRR were 100% and 83.33% respectively), and a manageable safety profile (only 1 patient experienced Gr \u22653 neurotoxicity (NT), no Gr \u22653 cytokine release syndrome (CRS)). Updated safety and efficacy data with a longer follow-up will be presented later.<\/p>\n\n\n\n

Preliminary Safety and Efficacy in Relapsed\/Refractory Mantle Cell Lymphoma<\/strong>
In this phase II single-arm open-label study in China, participants with MCL who underwent \u22652 lines of therapy including anti-CD20 antibody, anthracycline or bendamustine, and BTKis were included. After lymphodepleting chemotherapy, participants received relma-cel (100\u00d7106 CAR+ T cells). As of Nov 30, 2021, the preliminary data of relma-cel based on 11 patients provided promising clinical efficacy outcome (best ORR 81.8%, best CRR 54.5%) in high-risk patients with r\/r MCL and a low incidence of grade \u2265 3 CRS (1 patient) and immune effector cell-associated neurotoxicity syndrome (ICANS, 1 patient). This study is ongoing and further results will be presented.<\/p>\n\n\n\n

Relmacabtagene Autoleucel: Approved CAR-T Therapy<\/strong>
Relmacabtagene autoleucel, an autologous anti-CD19 CAR-T cell immunotherapy product independently developed by JW Therapeutics, has been approved to treat adult patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy, and adult patients with follicular lymphoma that is refractory or that relapse within 24 months of second-line or above systemic treatment (r\/r FL) in China.Fineline Info & Tech<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

China-based JW Therapeutics (HKG: 2126) presented the latest clinical data on Carteyva (relmacabtagene autoleucel injection)…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[7,11],"tags":[30,16,77,17,1165,321],"class_list":["post-23630","post","type-post","status-publish","format-standard","hentry","category-company","category-drug","tag-biotech","tag-cancer","tag-cell-therapy","tag-clinical-trial-results","tag-hkg-2126","tag-jw-therapeutics"],"yoast_head":"\nJW Therapeutics Presents Carteyva Data at ASH Annual Meeting - Insight, China's Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"China-based JW Therapeutics (HKG: 2126) presented the latest clinical data on Carteyva (relmacabtagene autoleucel injection) in Chinese adults with relapsed\/refractory follicular lymphoma (r\/r FL) and relapsed\/refractory mantle cell lymphoma (r\/r MCL) at the 64th American Society of Hematology (ASH) annual meeting.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/flcube.com\/?p=23630\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"JW Therapeutics Presents Carteyva Data at ASH Annual Meeting\" \/>\n<meta property=\"og:description\" content=\"Navigate the complexities of China\u2019s pharmaceutical industry with precision and clarity. 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