{"id":23730,"date":"2022-12-09T15:48:00","date_gmt":"2022-12-09T07:48:00","guid":{"rendered":"https:\/\/flcube.com\/?p=23730"},"modified":"2025-01-29T15:54:10","modified_gmt":"2025-01-29T07:54:10","slug":"remegens-rc118-receives-orphan-drug-designations-for-gastric-and-pancreatic-cancers","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=23730","title":{"rendered":"RemeGen&#8217;s RC118 Receives Orphan Drug Designations for Gastric and Pancreatic Cancers"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">China-based RemeGen Ltd announced that its antibody drug conjugate (ADC) drug candidate RC118 has obtained two orphan drug designations (ODD) from the US FDA, for the therapy&#8217;s potential use against gastric and pancreatic cancers.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>RC118: Mechanism and Development<\/strong><br>RC118, a novel ADC drug candidate co-developed with contract research organization (CRO) Biocytogen, is conjugated with the Claudin 18.2 monoclonal antibody (mAb) and the small molecule microtubule inhibitor monomethyl auristatin (MMAE). The drug is subject to a Phase I study in locally advanced unresectable or metastatic malignant solid tumors in patients with positive CLDN18.2 expression, and is undergoing a dosage ascending study, having shown a good safety and tolerability profile.<a href=\"https:\/\/flcube.com\/\">-Fineline Info &amp; Tech<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>China-based RemeGen Ltd announced that its antibody drug conjugate (ADC) drug candidate RC118 has obtained&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[7,11],"tags":[35,16,19,107,24,375],"class_list":["post-23730","post","type-post","status-publish","format-standard","hentry","category-company","category-drug","tag-adc-xdc","tag-cancer","tag-cro-cmo-cdmo","tag-immunotherapy","tag-rare-orphan-disease-drugs","tag-remegen"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.5 (Yoast SEO v27.9) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>RemeGen&#039;s RC118 Receives Orphan Drug Designations for Gastric and Pancreatic Cancers - Insight, China&#039;s Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"China-based RemeGen Ltd announced that its antibody drug conjugate (ADC) drug candidate RC118 has obtained two orphan drug designations (ODD) from the US FDA, for the therapy&#039;s potential use against gastric and pancreatic cancers.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/flcube.com\/?p=23730\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"RemeGen&#039;s RC118 Receives Orphan Drug Designations for Gastric and Pancreatic Cancers\" \/>\n<meta property=\"og:description\" content=\"Navigate the complexities of China\u2019s pharmaceutical industry with precision and clarity. 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