{"id":24340,"date":"2022-11-15T12:34:00","date_gmt":"2022-11-15T04:34:00","guid":{"rendered":"https:\/\/flcube.com\/?p=24340"},"modified":"2025-01-31T12:36:56","modified_gmt":"2025-01-31T04:36:56","slug":"innovent-biologics-initiates-phase-iii-trial-for-mazdutide-in-obesity","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=24340","title":{"rendered":"Innovent Biologics Initiates Phase III Trial for Mazdutide in Obesity"},"content":{"rendered":"\n

China-based Innovent Biologics, Inc. (HKG: 1801<\/a>) has announced the first patient dosing in the randomized, double-blind, placebo-controlled Phase III GLORY-1 study for its mazdutide (IBI362), a glucagon-like peptide-1 (GLP-1) and glucagon receptor dual agonist. The drug is being evaluated for the treatment of overweight or obese Chinese patients, marking a significant step in addressing obesity through innovative therapeutics.<\/p>\n\n\n\n

Study Design and Objectives<\/strong>
The GLORY-1 study is designed to assess the efficacy and safety of mazdutide in overweight or obese Chinese participants. It is recognized as the first regulatory study for a GLP-1 receptor\/glucagon receptor (GLP-1R\/GCGR) agonist in obesity globally. The study plans to enroll a total of 600 subjects, who will be randomly assigned to receive either mazdutide 4mg, mazdutide 6mg, or a placebo at a ratio of 1:1:1 for 48 weeks of treatment.<\/p>\n\n\n\n

Partnership and Drug Profile<\/strong>
Innovent previously entered into a licensing agreement with Eli Lilly and Company (Lilly) for the development and potential commercialization of OXM3, also known as mazdutide (IBI362) or LY3305677, in China. Mazdutide is a long-acting synthetic peptide related to mammalian oxyntomodulin (OXM). It incorporates a fatty acid side chain to extend its duration of action, enabling once-weekly administration. Mazdutide is believed to activate both GLP-1 and glucagon receptors in humans, improving glucose tolerance and inducing weight loss by mimicking the effects of endogenous oxyntomodulin.-Fineline Info & Tech<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

China-based Innovent Biologics, Inc. (HKG: 1801) has announced the first patient dosing in the randomized,…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[7,11],"tags":[62,910,198],"class_list":["post-24340","post","type-post","status-publish","format-standard","hentry","category-company","category-drug","tag-clinical-trial-approval-initiation","tag-hkg-1801","tag-innovent-biologics"],"yoast_head":"\nInnovent Biologics Initiates Phase III Trial for Mazdutide in Obesity - Insight, China's Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"China-based Innovent Biologics, Inc. 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