{"id":25263,"date":"2022-10-08T00:12:00","date_gmt":"2022-10-07T16:12:00","guid":{"rendered":"https:\/\/flcube.com\/?p=25263"},"modified":"2025-02-04T00:16:31","modified_gmt":"2025-02-03T16:16:31","slug":"connect-biopharmas-cbp-201-shows-positive-results-in-atopic-dermatitis-study","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=25263","title":{"rendered":"Connect Biopharma&#8217;s CBP-201 Shows Positive Results in Atopic Dermatitis Study"},"content":{"rendered":"\n<p>China-based Connect Biopharmaceuticals Ltd has announced the topline results of a pivotal clinical study for its monoclonal antibody (mAb) candidate, CBP-201, targeting allergic inflammation in moderate-to-severe atopic dermatitis (AD). The study was conducted across multiple centers in China and evaluated the efficacy and safety of CBP-201, as well as the potential for prolonged administration intervals through maintenance treatment.<\/p>\n\n\n\n<p><strong>Study Design and Results<\/strong><br>The multi-center, randomized, double-blinded, parallel, placebo-controlled study assessed CBP-201\u2019s efficacy and safety. At week 16, the proportion of subjects in the CBP-201 group (300mg, administered every two weeks) who achieved the primary endpoint\u2014an Investigator\u2019s Global Assessment (IGA) score of 0 or 1 with a reduction of \u22652 points from baseline\u2014was significantly higher than that in the placebo group (30.3% vs. 7.5%; p&lt;0.001).<\/p>\n\n\n\n<p><strong>Significant Improvements in Secondary Endpoints<\/strong><br>The CBP-201 group also demonstrated significantly higher proportions reaching EASI-50, EASI-75, and EASI-90 (Eczema Area and Severity Index score reduced by \u226550%, \u226575%, and \u226590% from baseline) compared to the placebo group (83.1% vs. 41.1%, 62.9% vs. 23.4%, 35.8% vs. 6.3%, all p values&lt;0.001). Additionally, 35% of subjects in the CBP-201 group experienced a \u22654-point reduction in the Peak Pruritus Numerical Rating Scale (PP-NRS) score compared to baseline, versus 9.6% in the placebo group (p&lt;0.001). The PP-NRS score showed a statistically significant decrease in the CBP-201 group from baseline within the first week after the first dose, indicating significant improvement in pruritus.<\/p>\n\n\n\n<p><strong>Safety and Tolerability<\/strong><br>The study results also indicated that CBP-201 was generally well-tolerated, with safety results comparable to those of the placebo. Most treatment-emergent adverse events (TEAEs) were mild to moderate and did not lead to drug withdrawal.<a href=\"https:\/\/flcube.com\/\">-Fineline Info &amp; Tech<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>China-based Connect Biopharmaceuticals Ltd has announced the topline results of a pivotal clinical study for&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[7,11],"tags":[65,30,17,248,107],"class_list":["post-25263","post","type-post","status-publish","format-standard","hentry","category-company","category-drug","tag-auto-immune","tag-biotech","tag-clinical-trial-results","tag-connect-biopharma","tag-immunotherapy"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v27.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Connect Biopharma&#039;s CBP-201 Shows Positive Results in Atopic Dermatitis Study - Insight, China&#039;s Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"China-based Connect Biopharmaceuticals Ltd has announced the topline results of a pivotal clinical study for its monoclonal antibody (mAb) candidate, CBP-201, targeting allergic inflammation in moderate-to-severe atopic dermatitis (AD). The study was conducted across multiple centers in China and evaluated the efficacy and safety of CBP-201, as well as the potential for prolonged administration intervals through maintenance treatment.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/flcube.com\/?p=25263\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Connect Biopharma&#039;s CBP-201 Shows Positive Results in Atopic Dermatitis Study\" \/>\n<meta property=\"og:description\" content=\"Navigate the complexities of China\u2019s pharmaceutical industry with precision and clarity. FLCUBE delivers reliable data, news, and intelligence to broaden your horizons and sharpen your decision-making. 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