{"id":26647,"date":"2025-02-13T21:58:47","date_gmt":"2025-02-13T13:58:47","guid":{"rendered":"https:\/\/flcube.com\/?p=26647"},"modified":"2025-02-13T21:58:49","modified_gmt":"2025-02-13T13:58:49","slug":"abbvie-collaborates-with-xilio-therapeutics-on-tumor-activated-immunotherapies","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=26647","title":{"rendered":"AbbVie Collaborates with Xilio Therapeutics on Tumor-Activated Immunotherapies"},"content":{"rendered":"\n

US pharmaceutical giant AbbVie (NYSE: ABBV<\/a>) has announced a collaboration and option-to-license agreement with fellow US firm Xilio Therapeutics, Inc. (NASDAQ: XLO<\/a>). The partnership aims to leverage Xilio’s proprietary technology to develop novel tumor-activated, antibody-based immunotherapies, including masked T-cell engagers.<\/p>\n\n\n\n

Details of the Collaboration<\/strong>
Xilio, with its proprietary, clinically-validated platform technology for tumor-activated biologics, is advancing a pipeline of innovative immunotherapies. These include masked multispecific molecules designed to achieve tumor-selective activation. The molecules use masking and other unique components optimized for specific targets, allowing focused activity within the tumor microenvironment. The goal is to minimize systemic adverse events.<\/p>\n\n\n\n

Financial Terms of the Agreement<\/strong>
Under the terms of the agreement, Xilio will receive USD52.0 million in upfront payments, including a USD10 million equity investment from AbbVie. Additionally, Xilio is eligible to receive up to USD2.1 billion in total contingent payments. These payments are for option-related fees and milestones, plus tiered royalties.-Fineline Info & Tech<\/a><\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

US pharmaceutical giant AbbVie (NYSE: ABBV) has announced a collaboration and option-to-license agreement with fellow…<\/p>\n","protected":false},"author":1,"featured_media":26649,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[7,10],"tags":[234,16,742,3645,853,3644],"class_list":["post-26647","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-company","category-deals","tag-abbvie","tag-cancer","tag-i-o-targets-2","tag-nasdaq-xlo","tag-nyse-abbv","tag-xilio-therapeutics"],"yoast_head":"\nAbbVie Collaborates with Xilio Therapeutics on Tumor-Activated Immunotherapies - Insight, China's Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"US pharmaceutical giant AbbVie (NYSE: ABBV) has announced a collaboration and option-to-license agreement with fellow US firm Xilio Therapeutics, Inc. 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