{"id":26660,"date":"2025-02-13T22:37:50","date_gmt":"2025-02-13T14:37:50","guid":{"rendered":"https:\/\/flcube.com\/?p=26660"},"modified":"2025-02-13T22:37:53","modified_gmt":"2025-02-13T14:37:53","slug":"oncusp-therapeutics-cusp06-receives-fda-fast-track-for-ovarian-cancer","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=26660","title":{"rendered":"OnCusp Therapeutics&#8217; CUSP06 Receives FDA Fast Track for Ovarian Cancer"},"content":{"rendered":"\n<p>Sino-US company OnCusp Therapeutics Inc. has announced that it has received Fast Track Designation (FTD) from the US Food and Drug Administration (FDA) for its CUSP06. CUSP06 is a Cadherin-6 targeting antibody-drug conjugate (CDH6 ADC). The targeted indication for this therapy is platinum-resistant ovarian cancer (PROC).<\/p>\n\n\n\n<p><strong>Drug Details<\/strong><br>CUSP06, the CDH6 ADC, is composed of a proprietary antibody with high CDH6 binding affinity. It also includes a protease-cleavable linker and an exatecan payload. Exatecan is a potent and clinically validated topoisomerase-1 inhibitor. The linker is designed to complement the exatecan payload. This enables a stable and homogenous ADC. The payload is a weak substrate for BCRP \/ P-gp. These are drug efflux pumps that drive chemoresistance to many therapies.<\/p>\n\n\n\n<p><strong>Development and Licensing<\/strong><br>The drug is currently being assessed in a Phase I study for platinum-refractory \/ resistant ovarian cancer and other advanced solid tumors. CUSP06 was obtained from China&#8217;s Multitude Therapeutics through a licensing deal in 2022. The agreement covers development and commercialization globally, excluding Greater China.<a href=\"https:\/\/flcube.com\/\">-Fineline Info &amp; Tech<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sino-US company OnCusp Therapeutics Inc. has announced that it has received Fast Track Designation (FTD)&#8230;<\/p>\n","protected":false},"author":1,"featured_media":26662,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[7,11],"tags":[35,16,1707],"class_list":["post-26660","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-company","category-drug","tag-adc-xdc","tag-cancer","tag-oncusp-therapeutics"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v27.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>OnCusp Therapeutics&#039; CUSP06 Receives FDA Fast Track for Ovarian Cancer - Insight, China&#039;s Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"Sino-US company OnCusp Therapeutics Inc. has announced that it has received Fast Track Designation (FTD) from the US Food and Drug Administration (FDA) for its CUSP06. CUSP06 is a Cadherin-6 targeting antibody-drug conjugate (CDH6 ADC). The targeted indication for this therapy is platinum-resistant ovarian cancer (PROC).\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/flcube.com\/?p=26660\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"OnCusp Therapeutics&#039; CUSP06 Receives FDA Fast Track for Ovarian Cancer\" \/>\n<meta property=\"og:description\" content=\"Sino-US company OnCusp Therapeutics Inc. has announced that it has received Fast Track Designation (FTD) from the US Food and Drug Administration (FDA) for its CUSP06. CUSP06 is a Cadherin-6 targeting antibody-drug conjugate (CDH6 ADC). 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