{"id":26723,"date":"2025-02-14T12:56:33","date_gmt":"2025-02-14T04:56:33","guid":{"rendered":"https:\/\/flcube.com\/?p=26723"},"modified":"2025-02-14T12:56:35","modified_gmt":"2025-02-14T04:56:35","slug":"mercks-zerbaxa-approved-by-chinas-nmpa-for-complex-infections","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=26723","title":{"rendered":"Merck’s Zerbaxa Approved by China’s NMPA for Complex Infections"},"content":{"rendered":"\n

US-based pharmaceutical giant Merck, Sharp & Dohme Inc. (MSD, NYSE: MRK<\/a>) announced that it has received marketing approval from the National Medical Products Administration (NMPA) for its antibiotic Zerbaxa (ceftolozane, tazobactam). The fixed-dose combination antibiotic medication is approved to treat a range of complex infections in both adult and pediatric patients.<\/p>\n\n\n\n

Approved Indications<\/strong>
Zerbaxa is approved for the treatment of complex intra-abdominal infections (cIAI) caused by sensitive gram-negative and gram-positive microorganisms, in combination with metronidazole. It is also approved for complex urinary tract infections (cUTIs), including pyelonephritis, caused by sensitive gram-negative microorganisms. Additionally, it is approved for hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VAPP) in adult patients (18 years and older) caused by sensitive gram-negative microorganisms.<\/p>\n\n\n\n

Context of Approval<\/strong>
Pseudomonas aeruginosa (PA) and Escherichia coli are common gram-negative bacteria in hospital-acquired infections in China. The proportion of drug-resistant Pseudomonas aeruginosa (MDRPA) in various types of infection patients in China is high, with 57.3% being multidrug-resistant. The mortality rate of lower respiratory tract infections caused by MDRPA is high, and treatment is difficult. The production of extended-spectrum \u03b2-lactase-producing Escherichia coli (ESBL-E) is also a significant clinical issue, with a detection rate of up to 62% in patients with urinary tract infections.-Fineline Info & Tech<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

US-based pharmaceutical giant Merck, Sharp & Dohme Inc. 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