{"id":26921,"date":"2022-08-12T22:14:00","date_gmt":"2022-08-12T14:14:00","guid":{"rendered":"https:\/\/flcube.com\/?p=26921"},"modified":"2025-02-15T22:17:13","modified_gmt":"2025-02-15T14:17:13","slug":"chinese-researchers-map-cancer-genomic-alterations-in-10000-patients","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=26921","title":{"rendered":"Chinese Researchers Map Cancer Genomic Alterations in 10,000 Patients"},"content":{"rendered":"\n

A team of Chinese researchers led by Wang Minghui at Sun Yat-sen University has conducted deep next-generation DNA sequencing (NGS) on tumor tissues and matched blood specimens from over 10,000 patients in China using a 450-gene comprehensive assay. The study provides a comprehensive comparison of somatically altered genes, the distribution of tumor mutational burden (TMB), gene fusion patterns, and the spectrum of various somatic alterations between Chinese and American patient populations.<\/p>\n\n\n\n

Study Findings<\/strong>
The major tumor types studied were non-small cell lung cancer (NSCLC; 20%), colorectal carcinoma (CRC; 12%), liver hepatocellular carcinoma (LIHC; 11%), gastric cancer (GC; 8%), esophageal carcinoma (ESCA; 6%), soft tissue sarcoma (STS; 6%), intrahepatic cholangiocarcinoma (ICC; 5%), pancreatic cancer (PAC; 5%), extrahepatic cholangiocarcinoma (ECC; 3%), and breast carcinoma (BRCA; 3%). These closely mirror clinical practice in China in terms of incidence and mortality.<\/p>\n\n\n\n

Among the findings, 64% of cancers in Chinese patients in the study were found to have clinically actionable genomic alterations. Analysis of significantly mutated cancer-related genes in solid tumors found the most frequently altered genes to be TP53 (58% of cases), KRAS (18%), TERT (14%), EGFR (13%), APC (13%), CDKN2A (12%), and PIK3CA (11%). The most common mutations were KRASG12, EGFRL858, and TP53R273. Genomic differences associated with clinical features were mainly distributed in colorectal cancer (CRC) and non-small cell lung cancer (NSCLC). For example, the study found that a high proportion of Chinese patients with lung cancer would likely benefit from immunotherapy.<\/p>\n\n\n\n

The study, titled \u201cLandscape of somatic alterations in large-scale solid tumors from an Asian population,\u201d was published in Nature Communications.-Fineline Info & Tech<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

A team of Chinese researchers led by Wang Minghui at Sun Yat-sen University has conducted…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[6],"tags":[742,109],"class_list":["post-26921","post","type-post","status-publish","format-standard","hentry","category-rd","tag-i-o-targets-2","tag-precision-medicine"],"yoast_head":"\nChinese Researchers Map Cancer Genomic Alterations in 10,000 Patients - Insight, China's Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"A team of Chinese researchers led by Wang Minghui at Sun Yat-sen University has conducted deep next-generation DNA sequencing (NGS) on tumor tissues and matched blood specimens from over 10,000 patients in China using a 450-gene comprehensive assay. 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