{"id":27153,"date":"2022-08-03T17:25:00","date_gmt":"2022-08-03T09:25:00","guid":{"rendered":"https:\/\/flcube.com\/?p=27153"},"modified":"2025-02-17T17:39:47","modified_gmt":"2025-02-17T09:39:47","slug":"aosaikangs-askg315-receives-ethics-approval-for-phase-i-cancer-trial-in-australia","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=27153","title":{"rendered":"Aosaikang’s ASKG315 Receives Ethics Approval for Phase I Cancer Trial in Australia"},"content":{"rendered":"\n

Beijing Aosaikang Pharmaceutical Co., Ltd (SHE: 002755<\/a>) announced it has received ethical approval from Australia’s Bellberry Human Research Ethics Committee (HREC) to initiate a Phase I clinical trial for ASKG315, its recombinant human interleukin-15 (IL-15) prodrug Fc fusion protein. The trial will assess the molecule in patients with advanced malignant solid tumors.<\/p>\n\n\n\n

Clinical Trial Approval<\/strong>
ASKG315, developed via Aosaikang’s SmartKine cytokine prodrug platform, will be tested for safety and efficacy in a Phase I study. The prodrug is designed to remain inactive in systemic circulation and activate only within the tumor microenvironment, targeting NK cells and Teff cells.<\/p>\n\n\n\n

Mechanism of Action<\/strong>
ASKG315’s tumor-specific activation minimizes systemic toxicity while enhancing immune cell stimulation. Preclinical studies confirmed its high binding activity post-activation and significant tumor growth inhibition across multiple models. The drug also boasts the longest half-life among similar cytokine therapies, enabling longer dosing intervals and cost efficiency.<\/p>\n\n\n\n

Company Background<\/strong>
Aosaikang, founded in 2015, focuses on innovative oncology therapies. The ASKG315 trial marks a milestone for its SmartKine platform, which aims to revolutionize cytokine-based cancer treatments.-Fineline Info & Tech<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Beijing Aosaikang Pharmaceutical Co., Ltd (SHE: 002755) announced it has received ethical approval from Australia’s…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[7,11],"tags":[955,16,1048],"class_list":["post-27153","post","type-post","status-publish","format-standard","hentry","category-company","category-drug","tag-aosaikang-pharmaceutical","tag-cancer","tag-she-002755"],"yoast_head":"\nAosaikang's ASKG315 Receives Ethics Approval for Phase I Cancer Trial in Australia - Insight, China's Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"Beijing Aosaikang Pharmaceutical Co., Ltd (SHE: 002755) announced it has received ethical approval from Australia's Bellberry Human Research Ethics Committee (HREC) to initiate a Phase I clinical trial for ASKG315, its recombinant human interleukin-15 (IL-15) prodrug Fc fusion protein. 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