{"id":29009,"date":"2025-03-10T23:50:21","date_gmt":"2025-03-10T15:50:21","guid":{"rendered":"https:\/\/flcube.com\/?p=29009"},"modified":"2025-03-10T23:50:24","modified_gmt":"2025-03-10T15:50:24","slug":"innocare-pharma-presents-positive-phase-ii-results-of-icp-488-in-psoriasis-at-aad-meeting","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=29009","title":{"rendered":"InnoCare Pharma Presents Positive Phase II Results of ICP-488 in Psoriasis at AAD Meeting"},"content":{"rendered":"\n<p>China-based InnoCare Pharma (<a href=\"https:\/\/www.google.com\/finance\/quote\/2142:HKG\">HKG: 9969<\/a>, <a href=\"https:\/\/www.google.com\/finance\/quote\/688428:SHA\">SHA: 688428<\/a>) announced the oral presentation of results from the Phase II study for its TYK2 (tyrosine kinase 2) JH2 allosteric inhibitor ICP-488 in psoriasis vulgaris at the American Academy of Dermatology Annual Meeting (AAD). The results demonstrate significant improvements in patients treated with ICP-488 compared to the placebo group.<\/p>\n\n\n\n<p><strong>Study Design and Patient Population<\/strong><br>The Phase II study randomized 129 psoriasis patients into three groups in a 1:1:1 ratio. Patients received 12 weeks of treatment in either the 6mg QD group, 9mg QD group, or placebo group. The primary endpoint was the proportion of patients achieving a 75% improvement in the Psoriasis Lesion Area and Severity Index (PASI75) at week 12.<\/p>\n\n\n\n<p><strong>Efficacy Results<\/strong><br>At week 12, the PASI75 response rates in the 6mg QD and 9mg QD groups were 77.3% and 78.6%, respectively, significantly higher than the placebo group&#8217;s 11.6% (P&lt;0.0001). Additionally, the PASI90 response rates in these two dose groups reached 36.4% and 50.0%, respectively, compared to 0% in the placebo group (P&lt;0.0001). The static Psoriasis Global Assessment (sPGA) 0\/1 response rates were 70.5% and 71.4% in the treatment groups, versus 9.3% in the placebo group (P&lt;0.0001).<\/p>\n\n\n\n<p><strong>Mechanism of Action<\/strong><br>ICP-488 is a potent and selective TYK2 allosteric inhibitor being developed for the treatment of psoriasis and other autoimmune diseases. By binding to the JH2 domain, ICP-488 blocks the signal transduction of inflammatory cytokines such as IL-23, IL-12, and type 1 IFN, thereby inhibiting the pathological process of autoimmune and inflammatory diseases.<\/p>\n\n\n\n<p><strong>Implications and Future Development<\/strong><br>These positive Phase II results position ICP-488 as a promising therapeutic option for psoriasis vulgaris. InnoCare Pharma plans to continue advancing the development of ICP-488, with further clinical trials expected to explore its efficacy and safety in larger patient populations.<a href=\"https:\/\/flcube.com\/\">-Fineline Info &amp; Tech<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>China-based InnoCare Pharma (HKG: 9969, SHA: 688428) announced the oral presentation of results from the&#8230;<\/p>\n","protected":false},"author":1,"featured_media":29011,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[7,11],"tags":[106,65,17,919,327,920],"class_list":["post-29009","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-company","category-drug","tag-academic-conference","tag-auto-immune","tag-clinical-trial-results","tag-hkg-9969","tag-innocare-pharma","tag-sha-688428"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v27.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>InnoCare Pharma Presents Positive Phase II Results of ICP-488 in Psoriasis at AAD Meeting - Insight, China&#039;s Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"China-based InnoCare Pharma (HKG: 9969, SHA: 688428) announced the oral presentation of results from the Phase II study for its TYK2 (tyrosine kinase 2) JH2 allosteric inhibitor ICP-488 in psoriasis vulgaris at the American Academy of Dermatology Annual Meeting (AAD). 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