{"id":30600,"date":"2022-06-19T18:26:00","date_gmt":"2022-06-19T10:26:00","guid":{"rendered":"https:\/\/flcube.com\/?p=30600"},"modified":"2025-03-26T18:28:02","modified_gmt":"2025-03-26T10:28:02","slug":"sirnaomics-stp705-shows-promising-results-in-skin-cancer-trial","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=30600","title":{"rendered":"Sirnaomics’ STP705 Shows Promising Results in Skin Cancer Trial"},"content":{"rendered":"\n

Sino-US siRNA therapy developer Sirnaomics Ltd (HKG: 2257<\/a>) announced the peer-reviewed publication of Phase IIa clinical study results of its lead therapeutic candidate, STP705, for the treatment of skin cancer, in the May 2022 issue of the Journal of Drugs in Dermatology (the “JDD”).<\/p>\n\n\n\n

Clinical Trial Results<\/strong>
The single-center, open-label, dose-escalation cohort study evaluated the safety and efficacy of various doses of intralesional injections of STP705 in patients with cutaneous squamous cell carcinoma. The primary endpoint was the proportion of patients achieving complete histological clearance. Among the 25 patients who received STP705, 19 (76%) achieved histological clearance. Specifically, 80% and 100% of patients in the 30 \u00b5g\/treatment and 60 \u00b5g\/treatment groups, respectively, achieved histological clearance. These results indicate that STP705 is non-invasive, safe, and effective in treating cutaneous in situ squamous cell carcinoma.<\/p>\n\n\n\n

Product Profile and Mechanism<\/strong>
STP705 is a siRNA therapeutic that leverages a dual-targeted inhibitory property and polypeptide nanoparticle (PNP)-enhanced delivery to directly knock down both TGF-\u03b21 and COX-2 gene expression. The product has received multiple Investigational New Drug (IND) approvals from both the US FDA and China\u2019s National Medical Products Administration for various indications, including cholangiocarcinoma, non-melanoma skin cancer, and hypertrophic scarring. It has also been granted Orphan Drug Designation for the treatment of cholangiocarcinoma and primary sclerosing cholangitis.<\/p>\n\n\n\n

Clinical Development<\/strong>
Currently, STP705 is being evaluated in five clinical trials for different indications: a Phase IIa trial for in situ squamous cell carcinoma (isSCC), a Phase II trial for basal cell carcinoma (BCC), Phase I\/II trials for keloid scarring and hypertrophic scar, and a Phase I trial for liver cancer (basket).-Fineline Info & Tech<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Sino-US siRNA therapy developer Sirnaomics Ltd (HKG: 2257) announced the peer-reviewed publication of Phase IIa…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[7,11],"tags":[16,17,845,64,440],"class_list":["post-30600","post","type-post","status-publish","format-standard","hentry","category-company","category-drug","tag-cancer","tag-clinical-trial-results","tag-hkg-2257","tag-rnai-aso","tag-sirnaomics"],"yoast_head":"\nSirnaomics' STP705 Shows Promising Results in Skin Cancer Trial - Insight, China's Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"Sino-US siRNA therapy developer Sirnaomics Ltd (HKG: 2257) announced the peer-reviewed publication of Phase IIa clinical study results of its lead therapeutic candidate, STP705, for the treatment of skin cancer, in the May 2022 issue of the Journal of Drugs in Dermatology (the "JDD").\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/flcube.com\/?p=30600\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sirnaomics' STP705 Shows Promising Results in Skin Cancer Trial\" \/>\n<meta property=\"og:description\" content=\"Navigate the complexities of China\u2019s pharmaceutical industry with precision and clarity. 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