{"id":30623,"date":"2022-06-19T18:51:00","date_gmt":"2022-06-19T10:51:00","guid":{"rendered":"https:\/\/flcube.com\/?p=30623"},"modified":"2025-03-26T18:53:41","modified_gmt":"2025-03-26T10:53:41","slug":"scotland-reports-first-case-of-ashep-ua-in-children-who-issues-guidelines","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=30623","title":{"rendered":"Scotland Reports First Case of ASHep-UA in Children, WHO Issues Guidelines"},"content":{"rendered":"\n

Scotland recorded its first case of acute severe hepatitis of unknown etiology in children (ASHep-UA) on March 31, 2022. Since then, multiple cases have emerged worldwide, with a higher proportion of severe instances. The European Centre for Disease Prevention and Control (ECDC) and the World Health Organization (WHO) updated their websites in early April with diagnostic recommendations. As of May 27, 2022, the WHO reported 650 suspected cases across 33 countries, with at least 38 requiring liver transplants and nine fatalities. China has yet to report any cases but has issued trial guidelines for diagnosis and treatment based on global data.<\/p>\n\n\n\n

Etiology and Pathogenesis<\/strong>
The WHO posits that while adenovirus infection might be a plausible cause for ASHep-UA, it typically causes mild, self-limiting gastrointestinal or respiratory infections in young children, insufficient to explain the severe clinical presentations observed. Most affected children globally have not received COVID-19 vaccines, suggesting the disease is unlikely linked to vaccination side effects.<\/p>\n\n\n\n

Clinical Manifestation<\/strong>
The disease presents with acute onset, primarily characterized by asthenia, anorexia, nausea, vomiting, diarrhea, and abdominal pain. These symptoms are followed by jaundice, dark urine, yellowing of the skin and sclera. Some children may experience pale stools, hepatomegaly, fever, respiratory symptoms, and splenomegaly. In severe cases, rapid progression to acute liver failure can occur, marked by worsening jaundice and hepatic encephalopathy.<\/p>\n\n\n\n

Treatment<\/strong>
Management should focus on comprehensive symptomatic and supportive care, close monitoring of condition changes, mental status assessment, laboratory indicator tracking, and prevention of complications. Patients with liver failure should be promptly transferred to specialized treatment centers.-Fineline Info & Tech<\/a><\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Scotland recorded its first case of acute severe hepatitis of unknown etiology in children (ASHep-UA)…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[4],"tags":[60,89],"class_list":["post-30623","post","type-post","status-publish","format-standard","hentry","category-policy-regulatory","tag-nhc-nhfpc","tag-viral-hepatitis"],"yoast_head":"\nScotland Reports First Case of ASHep-UA in Children, WHO Issues Guidelines - Insight, China's Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"Scotland recorded its first case of acute severe hepatitis of unknown etiology in children (ASHep-UA) on March 31, 2022. Since then, multiple cases have emerged worldwide, with a higher proportion of severe instances. The European Centre for Disease Prevention and Control (ECDC) and the World Health Organization (WHO) updated their websites in early April with diagnostic recommendations. As of May 27, 2022, the WHO reported 650 suspected cases across 33 countries, with at least 38 requiring liver transplants and nine fatalities. China has yet to report any cases but has issued trial guidelines for diagnosis and treatment based on global data.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/flcube.com\/?p=30623\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scotland Reports First Case of ASHep-UA in Children, WHO Issues Guidelines\" \/>\n<meta property=\"og:description\" content=\"Navigate the complexities of China\u2019s pharmaceutical industry with precision and clarity. FLCUBE delivers reliable data, news, and intelligence to broaden your horizons and sharpen your decision-making. Stay informed, stay ahead with FLCUBE.COM\" \/>\n<meta property=\"og:url\" content=\"https:\/\/flcube.com\/?p=30623\" \/>\n<meta property=\"og:site_name\" content=\"Insight, China's Pharmaceutical Industry\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/profile.php?id=61566606313834\" \/>\n<meta property=\"article:published_time\" content=\"2022-06-19T10:51:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-03-26T10:53:41+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/flcube.com\/wp-content\/uploads\/2024\/11\/Fineline-info-tech-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1894\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Fineline Cube\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Fineline Cube\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/flcube.com\\\/?p=30623#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/flcube.com\\\/?p=30623\"},\"author\":{\"name\":\"Fineline Cube\",\"@id\":\"https:\\\/\\\/flcube.com\\\/#\\\/schema\\\/person\\\/19ad11870d326204db8524d3c3c5e66a\"},\"headline\":\"Scotland Reports First Case of ASHep-UA in Children, WHO Issues Guidelines\",\"datePublished\":\"2022-06-19T10:51:00+00:00\",\"dateModified\":\"2025-03-26T10:53:41+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/flcube.com\\\/?p=30623\"},\"wordCount\":265,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/flcube.com\\\/#organization\"},\"keywords\":[\"NHC (NHFPC)\",\"Viral hepatitis\"],\"articleSection\":[\"Policy \\\/ Regulatory\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/flcube.com\\\/?p=30623#respond\"]}],\"copyrightYear\":\"2022\",\"copyrightHolder\":{\"@id\":\"https:\\\/\\\/flcube.com\\\/#organization\"}},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/flcube.com\\\/?p=30623\",\"url\":\"https:\\\/\\\/flcube.com\\\/?p=30623\",\"name\":\"Scotland Reports First Case of ASHep-UA in Children, WHO Issues Guidelines - Insight, China's Pharmaceutical Industry\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/flcube.com\\\/#website\"},\"datePublished\":\"2022-06-19T10:51:00+00:00\",\"dateModified\":\"2025-03-26T10:53:41+00:00\",\"description\":\"Scotland recorded its first case of acute severe hepatitis of unknown etiology in children (ASHep-UA) on March 31, 2022. Since then, multiple cases have emerged worldwide, with a higher proportion of severe instances. The European Centre for Disease Prevention and Control (ECDC) and the World Health Organization (WHO) updated their websites in early April with diagnostic recommendations. As of May 27, 2022, the WHO reported 650 suspected cases across 33 countries, with at least 38 requiring liver transplants and nine fatalities. China has yet to report any cases but has issued trial guidelines for diagnosis and treatment based on global data.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/flcube.com\\\/?p=30623#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/flcube.com\\\/?p=30623\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/flcube.com\\\/?p=30623#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/flcube.com\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Scotland Reports First Case of ASHep-UA in Children, WHO Issues Guidelines\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/flcube.com\\\/#website\",\"url\":\"https:\\\/\\\/flcube.com\\\/\",\"name\":\"Insight, China's Pharmaceutical Industry\",\"description\":\"Fineline Insights, Pharma Clarity\",\"publisher\":{\"@id\":\"https:\\\/\\\/flcube.com\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/flcube.com\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/flcube.com\\\/#organization\",\"name\":\"Fineline Infomation and Technology\",\"alternateName\":\"Fineline Info & Tech\",\"url\":\"https:\\\/\\\/flcube.com\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/flcube.com\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/flcube.com\\\/wp-content\\\/uploads\\\/2024\\\/11\\\/Fineline-info-tech-scaled.jpg\",\"contentUrl\":\"https:\\\/\\\/flcube.com\\\/wp-content\\\/uploads\\\/2024\\\/11\\\/Fineline-info-tech-scaled.jpg\",\"width\":2560,\"height\":1894,\"caption\":\"Fineline Infomation and Technology\"},\"image\":{\"@id\":\"https:\\\/\\\/flcube.com\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/profile.php?id=61566606313834\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/flcube.com\\\/#\\\/schema\\\/person\\\/19ad11870d326204db8524d3c3c5e66a\",\"name\":\"Fineline Cube\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/89f733aaed3d2d91d7d6f45d0e9ab509e3004e8243c6e57620b36380684657f2?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/89f733aaed3d2d91d7d6f45d0e9ab509e3004e8243c6e57620b36380684657f2?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/89f733aaed3d2d91d7d6f45d0e9ab509e3004e8243c6e57620b36380684657f2?s=96&d=mm&r=g\",\"caption\":\"Fineline Cube\"},\"sameAs\":[\"https:\\\/\\\/flcube.com\"],\"url\":\"https:\\\/\\\/flcube.com\\\/?author=1\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Scotland Reports First Case of ASHep-UA in Children, WHO Issues Guidelines - Insight, China's Pharmaceutical Industry","description":"Scotland recorded its first case of acute severe hepatitis of unknown etiology in children (ASHep-UA) on March 31, 2022. Since then, multiple cases have emerged worldwide, with a higher proportion of severe instances. The European Centre for Disease Prevention and Control (ECDC) and the World Health Organization (WHO) updated their websites in early April with diagnostic recommendations. As of May 27, 2022, the WHO reported 650 suspected cases across 33 countries, with at least 38 requiring liver transplants and nine fatalities. China has yet to report any cases but has issued trial guidelines for diagnosis and treatment based on global data.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/flcube.com\/?p=30623","og_locale":"en_US","og_type":"article","og_title":"Scotland Reports First Case of ASHep-UA in Children, WHO Issues Guidelines","og_description":"Navigate the complexities of China\u2019s pharmaceutical industry with precision and clarity. FLCUBE delivers reliable data, news, and intelligence to broaden your horizons and sharpen your decision-making. Stay informed, stay ahead with FLCUBE.COM","og_url":"https:\/\/flcube.com\/?p=30623","og_site_name":"Insight, China's Pharmaceutical Industry","article_publisher":"https:\/\/www.facebook.com\/profile.php?id=61566606313834","article_published_time":"2022-06-19T10:51:00+00:00","article_modified_time":"2025-03-26T10:53:41+00:00","og_image":[{"width":2560,"height":1894,"url":"https:\/\/flcube.com\/wp-content\/uploads\/2024\/11\/Fineline-info-tech-scaled.jpg","type":"image\/jpeg"}],"author":"Fineline Cube","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Fineline Cube","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/flcube.com\/?p=30623#article","isPartOf":{"@id":"https:\/\/flcube.com\/?p=30623"},"author":{"name":"Fineline Cube","@id":"https:\/\/flcube.com\/#\/schema\/person\/19ad11870d326204db8524d3c3c5e66a"},"headline":"Scotland Reports First Case of ASHep-UA in Children, WHO Issues Guidelines","datePublished":"2022-06-19T10:51:00+00:00","dateModified":"2025-03-26T10:53:41+00:00","mainEntityOfPage":{"@id":"https:\/\/flcube.com\/?p=30623"},"wordCount":265,"commentCount":0,"publisher":{"@id":"https:\/\/flcube.com\/#organization"},"keywords":["NHC (NHFPC)","Viral hepatitis"],"articleSection":["Policy \/ Regulatory"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/flcube.com\/?p=30623#respond"]}],"copyrightYear":"2022","copyrightHolder":{"@id":"https:\/\/flcube.com\/#organization"}},{"@type":"WebPage","@id":"https:\/\/flcube.com\/?p=30623","url":"https:\/\/flcube.com\/?p=30623","name":"Scotland Reports First Case of ASHep-UA in Children, WHO Issues Guidelines - Insight, China's Pharmaceutical Industry","isPartOf":{"@id":"https:\/\/flcube.com\/#website"},"datePublished":"2022-06-19T10:51:00+00:00","dateModified":"2025-03-26T10:53:41+00:00","description":"Scotland recorded its first case of acute severe hepatitis of unknown etiology in children (ASHep-UA) on March 31, 2022. Since then, multiple cases have emerged worldwide, with a higher proportion of severe instances. The European Centre for Disease Prevention and Control (ECDC) and the World Health Organization (WHO) updated their websites in early April with diagnostic recommendations. As of May 27, 2022, the WHO reported 650 suspected cases across 33 countries, with at least 38 requiring liver transplants and nine fatalities. China has yet to report any cases but has issued trial guidelines for diagnosis and treatment based on global data.","breadcrumb":{"@id":"https:\/\/flcube.com\/?p=30623#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/flcube.com\/?p=30623"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/flcube.com\/?p=30623#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/flcube.com\/"},{"@type":"ListItem","position":2,"name":"Scotland Reports First Case of ASHep-UA in Children, WHO Issues Guidelines"}]},{"@type":"WebSite","@id":"https:\/\/flcube.com\/#website","url":"https:\/\/flcube.com\/","name":"Insight, China's Pharmaceutical Industry","description":"Fineline Insights, Pharma Clarity","publisher":{"@id":"https:\/\/flcube.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/flcube.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/flcube.com\/#organization","name":"Fineline Infomation and Technology","alternateName":"Fineline Info & Tech","url":"https:\/\/flcube.com\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/flcube.com\/#\/schema\/logo\/image\/","url":"https:\/\/flcube.com\/wp-content\/uploads\/2024\/11\/Fineline-info-tech-scaled.jpg","contentUrl":"https:\/\/flcube.com\/wp-content\/uploads\/2024\/11\/Fineline-info-tech-scaled.jpg","width":2560,"height":1894,"caption":"Fineline Infomation and Technology"},"image":{"@id":"https:\/\/flcube.com\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/profile.php?id=61566606313834"]},{"@type":"Person","@id":"https:\/\/flcube.com\/#\/schema\/person\/19ad11870d326204db8524d3c3c5e66a","name":"Fineline Cube","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/89f733aaed3d2d91d7d6f45d0e9ab509e3004e8243c6e57620b36380684657f2?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/89f733aaed3d2d91d7d6f45d0e9ab509e3004e8243c6e57620b36380684657f2?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/89f733aaed3d2d91d7d6f45d0e9ab509e3004e8243c6e57620b36380684657f2?s=96&d=mm&r=g","caption":"Fineline Cube"},"sameAs":["https:\/\/flcube.com"],"url":"https:\/\/flcube.com\/?author=1"}]}},"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/flcube.com\/index.php?rest_route=\/wp\/v2\/posts\/30623","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/flcube.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/flcube.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/flcube.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/flcube.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=30623"}],"version-history":[{"count":1,"href":"https:\/\/flcube.com\/index.php?rest_route=\/wp\/v2\/posts\/30623\/revisions"}],"predecessor-version":[{"id":30624,"href":"https:\/\/flcube.com\/index.php?rest_route=\/wp\/v2\/posts\/30623\/revisions\/30624"}],"wp:attachment":[{"href":"https:\/\/flcube.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=30623"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/flcube.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=30623"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/flcube.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=30623"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}