{"id":30798,"date":"2022-06-13T18:31:00","date_gmt":"2022-06-13T10:31:00","guid":{"rendered":"https:\/\/flcube.com\/?p=30798"},"modified":"2025-03-27T18:32:39","modified_gmt":"2025-03-27T10:32:39","slug":"oncusp-therapeutics-licenses-multitudes-cdh6-adc-for-global-development","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=30798","title":{"rendered":"OnCusp Therapeutics Licenses Multitude&#8217;s CDH6 ADC for Global Development"},"content":{"rendered":"\n<p>US-based OnCusp Therapeutics has entered into a licensing agreement with China\u2019s Multitude Therapeutics for the global development and commercialization of AMT-707 (CUSP06), a preclinical-stage cadherin-6 (CDH6) antibody-drug conjugate (ADC). OnCusp gains exclusive rights outside Greater China, while Multitude receives undisclosed upfront, milestone payments, and royalties.<\/p>\n\n\n\n<p><strong>Scientific Rationale and Drug Profile<\/strong><br>CDH6 is highly expressed in ovarian and renal cancers and linked to other solid tumors. Multitude designed CUSP06 with high CDH6 binding affinity, a protease-cleavable linker, and an exatecan payload. Preclinical data suggest its linker\/payload may enhance the &#8220;bystander effect&#8221; compared to competitor ADCs.<\/p>\n\n\n\n<p><strong>Collaboration and Development Plans<\/strong><br>OnCusp and Multitude have engaged WuXi XDC for CMC services, with IND-enabling studies underway. OnCusp, a Sino-US firm with offices in New York and Shanghai, focuses on in-licensing preclinical candidates and advancing them to proof-of-concept before out-licensing.<\/p>\n\n\n\n<p><strong>OnCusp&#8217;s Background<\/strong><br>Founded in April 2021 by Dr. Bing Yuan, former CStone executive, OnCusp secured $25 million in seed funding from investors including Sequoia Capital China and BioTrack Capital.<a href=\"https:\/\/flcube.com\/\">-Fineline Info &amp; Tech<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>US-based OnCusp Therapeutics has entered into a licensing agreement with China\u2019s Multitude Therapeutics for the&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[7,10],"tags":[35,16,1707],"class_list":["post-30798","post","type-post","status-publish","format-standard","hentry","category-company","category-deals","tag-adc-xdc","tag-cancer","tag-oncusp-therapeutics"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.5 (Yoast SEO v27.6) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>OnCusp Therapeutics Licenses Multitude&#039;s CDH6 ADC for Global Development - Insight, China&#039;s Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"US-based OnCusp Therapeutics has entered into a licensing agreement with China\u2019s Multitude Therapeutics for the global development and commercialization of AMT-707 (CUSP06), a preclinical-stage cadherin-6 (CDH6) antibody-drug conjugate (ADC). 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