{"id":34247,"date":"2025-05-27T16:18:20","date_gmt":"2025-05-27T08:18:20","guid":{"rendered":"https:\/\/flcube.com\/?p=34247"},"modified":"2025-05-27T16:18:21","modified_gmt":"2025-05-27T08:18:21","slug":"beigene-and-amgen-report-positive-results-for-tarlatamab-in-chinese-es-sclc-patients","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=34247","title":{"rendered":"BeiGene and Amgen Report Positive Results for Tarlatamab in Chinese ES-SCLC Patients"},"content":{"rendered":"\n<p>BeiGene, Ltd. (<a href=\"https:\/\/www.google.com\/finance\/quote\/ONC:NASDAQ\">NASDAQ: ONC<\/a>, <a href=\"https:\/\/www.google.com\/finance\/quote\/6160:HKG\">HKG: 6160<\/a>, <a href=\"https:\/\/www.google.com\/finance\/quote\/688235:SHA\">SHA: 688235<\/a>), a China-based oncology company proposing to rename itself BeOne Medicines Ltd., announced positive results from the Phase II clinical trial DeLLphi-307 (NCT06502977) for tarlatamab, conducted in collaboration with US biotech Amgen (<a href=\"https:\/\/www.google.com\/finance\/quote\/AMGN:NASDAQ\">NASDAQ: AMGN<\/a>) in China. The trial highlights the drug&#8217;s potential in treating extensive-stage small cell lung cancer (ES-SCLC).<\/p>\n\n\n\n<p><strong>Tarlatamab Mechanism and Development<\/strong><br>Tarlatamab is a bispecific T-cell engager (BiTE) targeting DLL3 and CD3, designed to bind to DLL3 on tumor cells and CD3 on T cells. Through its global oncology collaboration with Amgen, BeiGene is co-developing and commercializing tarlatamab in China, with plans to submit a marketing application for relevant indications within the year.<\/p>\n\n\n\n<p><strong>Clinical Trial Details<\/strong><br>The DeLLphi-307 trial assessed the efficacy, safety, and tolerability of tarlatamab in Chinese patients with ES-SCLC who had failed at least two prior lines of therapy, including platinum-based chemotherapy. The primary endpoint of the trial was objective response rate (ORR). Detailed data from the trial will be presented at an upcoming medical conference.<\/p>\n\n\n\n<p><strong>Previous Trial Results<\/strong><br>Earlier Phase II (DeLLphi-301) and Phase III (DeLLphi-304) trials of tarlatamab for second-line SCLC treatment also demonstrated positive results. Based on data from DeLLphi-301, the U.S. FDA granted tarlatamab accelerated approval for this indication.<a href=\"https:\/\/flcube.com\/\">-Fineline Info &amp; Tech<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>BeiGene, Ltd. (NASDAQ: ONC, HKG: 6160, SHA: 688235), a China-based oncology company proposing to rename&#8230;<\/p>\n","protected":false},"author":1,"featured_media":34248,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[7,11],"tags":[330,185,2092,17,847,912,3046,848],"class_list":["post-34247","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-company","category-drug","tag-amgen","tag-beigene","tag-beone-medicines","tag-clinical-trial-results","tag-hkg-6160","tag-nasdaq-amgn","tag-nasdaq-onc","tag-sha-688235"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>BeiGene and Amgen Report Positive Results for Tarlatamab in Chinese ES-SCLC Patients - Insight, China&#039;s Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"BeiGene, Ltd. (NASDAQ: ONC, HKG: 6160, SHA: 688235), a China-based oncology company proposing to rename itself BeOne Medicines Ltd., announced positive results from the Phase II clinical trial DeLLphi-307 (NCT06502977) for tarlatamab, conducted in collaboration with US biotech Amgen (Nasdaq: AMGN) in China. The trial highlights the drug&#039;s potential in treating extensive-stage small cell lung cancer (ES-SCLC).\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/flcube.com\/?p=34247\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"BeiGene and Amgen Report Positive Results for Tarlatamab in Chinese ES-SCLC Patients\" \/>\n<meta property=\"og:description\" content=\"BeiGene, Ltd. (NASDAQ: ONC, HKG: 6160, SHA: 688235), a China-based oncology company proposing to rename itself BeOne Medicines Ltd., announced positive results from the Phase II clinical trial DeLLphi-307 (NCT06502977) for tarlatamab, conducted in collaboration with US biotech Amgen (Nasdaq: AMGN) in China. 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