{"id":34690,"date":"2025-06-04T15:36:28","date_gmt":"2025-06-04T07:36:28","guid":{"rendered":"https:\/\/flcube.com\/?p=34690"},"modified":"2025-06-04T15:36:29","modified_gmt":"2025-06-04T07:36:29","slug":"legend-biotech-presents-5-year-carvykti-data-at-asco-2025","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=34690","title":{"rendered":"Legend Biotech Presents 5-Year Carvykti Data at ASCO 2025"},"content":{"rendered":"\n

China-based Legend Biotech Corporation (NASDAQ: LEGN<\/a>) presented 5-year follow-up data from the CARTITUDE-1 study for Carvykti (ciltacabtagene autoleucel) at the ASCO 2025 Annual Meeting. The data revealed unprecedented long-term outcomes in patients with relapsed or refractory multiple myeloma (RRMM).<\/p>\n\n\n\n

Long-Term Outcomes<\/strong>
The results showed that 33% (32\/97) of treated patients remained progression-free for \u22655 years after a single infusion, with no subsequent myeloma therapy required. The median overall survival (OS) reached 60.7 months (95% CI: 41.9\u2013Not Reached), demonstrating a durable clinical benefit. Additionally, MRD-negative patients showed no signs of relapse in annual PET\/CT scans over 5 years.<\/p>\n\n\n\n

Safety Profile<\/strong>
In terms of safety, no new cases of movement disorders or neurocognitive toxicity were observed, although two new secondary primary malignancies (both solid tumors) were reported.<\/p>\n\n\n\n

CARTITUDE-4 Study<\/strong>
Furthermore, the CARTITUDE-4 study confirmed consistent progression-free survival (PFS) and OS benefits across high-risk subgroups, including patients with adverse cytogenetic profiles, extramedullary disease (EMD), and heavy prior treatment exposure.-Fineline Info & Tech<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

China-based Legend Biotech Corporation (NASDAQ: LEGN) presented 5-year follow-up data from the CARTITUDE-1 study for…<\/p>\n","protected":false},"author":1,"featured_media":34691,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[7,11],"tags":[106,16,17,112,873],"class_list":["post-34690","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-company","category-drug","tag-academic-conference","tag-cancer","tag-clinical-trial-results","tag-legend-biotech","tag-nasdaq-legn"],"yoast_head":"\nLegend Biotech Presents 5-Year Carvykti Data at ASCO 2025 - Insight, China's Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"China-based Legend Biotech Corporation (NASDAQ: LEGN) presented 5-year follow-up data from the CARTITUDE-1 study for Carvykti (ciltacabtagene autoleucel) at the ASCO 2025 Annual Meeting. 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