{"id":36359,"date":"2025-07-01T15:26:57","date_gmt":"2025-07-01T07:26:57","guid":{"rendered":"https:\/\/flcube.com\/?p=36359"},"modified":"2025-07-01T15:26:57","modified_gmt":"2025-07-01T07:26:57","slug":"fosun-pharma-secures-licensing-deal-for-hcb101-sirp%ce%b1-fc-fusion-protein","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=36359","title":{"rendered":"Fosun Pharma Secures Licensing Deal for HCB101 SIRP\u03b1-Fc Fusion Protein"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Shanghai-based Fosun Pharmaceutical (Group) Co., Ltd (<a href=\"https:\/\/www.google.com\/finance\/quote\/2196:HKG\">HKG: 2196<\/a>, <a href=\"https:\/\/www.google.com\/finance\/quote\/600196:SHA\">SHA: 600196<\/a>) has entered into a licensing agreement with Taiwan-based HanchorBio. This collaboration grants Fosun exclusive rights to develop, manufacture, and commercialize HanchorBio\u2019s SIRP\u03b1-Fc fusion protein HCB101 in China (excluding Taiwan), selected Southeast Asian countries, and specific MENA region nations, with priority negotiation rights for Japan.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Licensing Agreement<\/strong><br>Under the terms of the agreement, HanchorBio will receive an upfront payment of USD 10 million and is eligible for USD 192 million in milestone payments, along with sales royalties.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Drug Profile<\/strong><br>HCB101 is a potential best-in-class Fc fused SIRP alpha variant. It is formed by fusing the engineered IgV domain of human signal regulatory protein alpha (SIRP alpha) with the IgG4Fc domain. Compared to traditional anti-CD47 monoclonal antibodies, HCB101 offers significant advantages in optimizing immune activation and reducing hematological toxicity.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Clinical Development<\/strong><br>HCB101 is currently undergoing Phase Ib\/IIa clinical studies in combination with standard therapy for advanced solid tumors in China, the US, and other regions. Preliminary results indicate efficacy and good safety, both as a standalone treatment and in combination with other drugs.<a href=\"https:\/\/flcube.com\/\">-Fineline Info &amp; Tech<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Shanghai-based Fosun Pharmaceutical (Group) Co., Ltd (HKG: 2196, SHA: 600196) has entered into a licensing&#8230;<\/p>\n","protected":false},"author":1,"featured_media":36362,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[7,10],"tags":[30,159,2308,893,892],"class_list":["post-36359","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-company","category-deals","tag-biotech","tag-fosun-pharmaceutical","tag-hanchorbio","tag-hkg-2196","tag-sha-600196"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.5 (Yoast SEO v27.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Fosun Pharma Secures Licensing Deal for HCB101 SIRP\u03b1-Fc Fusion Protein - Insight, China&#039;s Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"Shanghai-based Fosun Pharmaceutical (Group) Co., Ltd (HKG: 2196, SHA: 600196) has entered into a licensing agreement with Taiwan-based HanchorBio. 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