{"id":36588,"date":"2025-07-03T16:52:00","date_gmt":"2025-07-03T08:52:00","guid":{"rendered":"https:\/\/flcube.com\/?p=36588"},"modified":"2025-07-03T16:52:01","modified_gmt":"2025-07-03T08:52:01","slug":"sichuan-biokins-iza-bren-meets-primary-endpoint-in-phase-iii-npc-trial","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=36588","title":{"rendered":"Sichuan Biokin&#8217;s Iza-bren Meets Primary Endpoint in Phase III NPC Trial"},"content":{"rendered":"\n<p>China-based Sichuan Biokin Pharmaceutical Co., Ltd (<a href=\"https:\/\/www.google.com\/finance\/quote\/688506:SHA\">SHA: 688506<\/a>) announced that its Phase III clinical study for iza-bren, an EGFR\u00d7HER3 bispecific antibody drug conjugate (ADC), has met the primary endpoint in an interim analysis. The study focused on recurrent\/metastatic nasopharyngeal carcinoma (NPC) that has failed PD-1\/PD-L1 monoclonal antibody therapy and progressed after \u22652 prior chemotherapy lines, including \u22651 platinum-based regimen.<\/p>\n\n\n\n<p><strong>Iza-bren: A First-in-Class ADC<\/strong><br>Iza-bren is the world&#8217;s first and only EGFR\u00d7HER3 bispecific ADC to reach Phase III clinical development. The drug is currently the subject of over 40 clinical studies across multiple tumor types.<\/p>\n\n\n\n<p><strong>Regulatory Recognition<\/strong><br>To date, iza-bren has received Breakthrough Therapy Designations from China&#8217;s National Medical Products Administration (NMPA) for five different indications.<a href=\"https:\/\/flcube.com\/\">-Fineline Info &amp; Tech<\/a><\/p>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/flcube.com\/wp-content\/uploads\/2025\/07\/688506_20250703_96T7.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Embed of 688506_20250703_96T7.\"><\/object><a id=\"wp-block-file--media-ae3a1ecc-8b07-4c68-8317-58f15507ddc5\" href=\"https:\/\/flcube.com\/wp-content\/uploads\/2025\/07\/688506_20250703_96T7.pdf\">688506_20250703_96T7<\/a><a href=\"https:\/\/flcube.com\/wp-content\/uploads\/2025\/07\/688506_20250703_96T7.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-ae3a1ecc-8b07-4c68-8317-58f15507ddc5\">Download<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>China-based Sichuan Biokin Pharmaceutical Co., Ltd (SHA: 688506) announced that its Phase III clinical study&#8230;<\/p>\n","protected":false},"author":1,"featured_media":36590,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[7,11],"tags":[35,151,16,17,857],"class_list":["post-36588","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-company","category-drug","tag-adc-xdc","tag-biokin-pharmaceutical","tag-cancer","tag-clinical-trial-results","tag-sha-688506"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v27.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Sichuan Biokin&#039;s Iza-bren Meets Primary Endpoint in Phase III NPC Trial - Insight, China&#039;s Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"China-based Sichuan Biokin Pharmaceutical Co., Ltd (SHA: 688506) announced that its Phase III clinical study for iza-bren, an EGFR\u00d7HER3 bispecific antibody drug conjugate (ADC), has met the primary endpoint in an interim analysis. The study focused on recurrent\/metastatic nasopharyngeal carcinoma (NPC) that has failed PD-1\/PD-L1 monoclonal antibody therapy and progressed after \u22652 prior chemotherapy lines, including \u22651 platinum-based regimen.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/flcube.com\/?p=36588\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sichuan Biokin&#039;s Iza-bren Meets Primary Endpoint in Phase III NPC Trial\" \/>\n<meta property=\"og:description\" content=\"China-based Sichuan Biokin Pharmaceutical Co., Ltd (SHA: 688506) announced that its Phase III clinical study for iza-bren, an EGFR\u00d7HER3 bispecific antibody drug conjugate (ADC), has met the primary endpoint in an interim analysis. 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