{"id":4060,"date":"2024-04-30T18:22:49","date_gmt":"2024-04-30T10:22:49","guid":{"rendered":"https:\/\/flcube.com\/?p=4060"},"modified":"2024-10-23T18:25:12","modified_gmt":"2024-10-23T10:25:12","slug":"eoc-pharmas-entinostat-secures-chinese-approval-for-breast-cancer-treatment","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=4060","title":{"rendered":"EOC Pharma&#8217;s Entinostat Secures Chinese Approval for Breast Cancer Treatment"},"content":{"rendered":"\n<p>US-China biotech firm EOC Pharma has received market approval from China\u2019s National Medical Products Administration (NMPA) for its entinostat, an oral histone deacetylase (HDAC) inhibitor, for the treatment of locally advanced or metastatic breast cancer in patients with hormone receptor (HR) positive and human epidermal growth factor receptor-2 (HER2) negative status after endocrine therapy combined with an aromatase inhibitor.<\/p>\n\n\n\n<p>A pivotal Phase III clinical trial, which was randomized, double-blinded, and placebo-controlled, evaluated the drug&#8217;s combination with exemestane as a treatment for HR+, HER2- advanced breast cancer and met its pre-set primary endpoint. The study demonstrated that the entinostat and exemestane combination significantly improved progression-free survival (PFS) in patients with advanced breast cancer who had previously failed endocrine therapy, with a PFS hazard ratio (HR) of 0.76. There was also a trend indicating a benefit in overall survival (OS) with a HR of 0.837, while the safety profile of the combination was favorable.- <a href=\"https:\/\/flcube.com\">Flcube.com<\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>US-China biotech firm EOC Pharma has received market approval from China\u2019s National Medical Products Administration&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[7,11],"tags":[16,834,15],"class_list":["post-4060","post","type-post","status-publish","format-standard","hentry","category-company","category-drug","tag-cancer","tag-eoc-pharma","tag-product-approvals"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v27.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>EOC Pharma&#039;s Entinostat Secures Chinese Approval for Breast Cancer Treatment - Insight, China&#039;s Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"US-China biotech firm EOC Pharma has received market approval from China\u2019s National Medical Products Administration (NMPA) for its entinostat, an oral histone deacetylase (HDAC) inhibitor, for the treatment of locally advanced or metastatic breast cancer in patients with hormone receptor (HR) positive and human epidermal growth factor receptor-2 (HER2) negative status after endocrine therapy combined with an aromatase inhibitor.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/flcube.com\/?p=4060\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"EOC Pharma&#039;s Entinostat Secures Chinese Approval for Breast Cancer Treatment\" \/>\n<meta property=\"og:description\" content=\"Navigate the complexities of China\u2019s pharmaceutical industry with precision and clarity. 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