{"id":44597,"date":"2025-10-27T22:03:04","date_gmt":"2025-10-27T14:03:04","guid":{"rendered":"https:\/\/flcube.com\/?p=44597"},"modified":"2025-10-27T22:03:06","modified_gmt":"2025-10-27T14:03:06","slug":"innovents-mazdutide-meets-phase-iii-endpoint-in-type-2-diabetes-and-obesity-trial","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=44597","title":{"rendered":"Innovent’s Mazdutide Meets Phase III Endpoint in Type 2 Diabetes and Obesity Trial"},"content":{"rendered":"\n

Innovent Biologics (HKG: 1801<\/a>) announced on October 27, 2025, that its fourth Phase III clinical study (DREAMS-3) for Mazdutide (IBI362), a Glucagon (GCG)\/Glucagon-like Peptide-1 (GLP-1) dual receptor agonist, has met its primary endpoint.<\/p>\n\n\n\n

Clinical Trial Results<\/strong>
The trial results indicated that in Chinese participants with Type 2 Diabetes (T2D) and comorbid obesity, the Mazdutide group achieved significantly better outcomes compared to the Semaglutide group. At Week 32, 48.0% of Mazdutide-treated participants achieved an HbA1c < 7.0% and a body weight reduction of \u226510% from baseline, compared to 21.0% in the Semaglutide group (P-value < 0.0001). The mean change in HbA1c from baseline was -2.03% in the Mazdutide group versus -1.84% in the Semaglutide group, while the mean percentage body weight reduction was 10.29% and 6.00%, respectively (both P-values < 0.05).<\/p>\n\n\n\n

Safety Profile<\/strong>
Mazdutide demonstrated a safety profile consistent with previous trials, with no new safety signals identified. Gastrointestinal adverse reactions were the most common, mostly mild to moderate in severity.<\/p>\n\n\n\n

Mechanism and Development<\/strong>
Mazdutide, co-developed by Innovent Biologics and Eli Lilly, is a mammalian oxyntomodulin (OXM) analog. It lowers blood glucose and reduces body weight by activating GLP-1R and increases energy expenditure by activating GCGR. Approved for marketing in China in June 2025, Mazdutide offers a novel approach to managing T2D and obesity.-Fineline Info & Tech<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Innovent Biologics (HKG: 1801) announced on October 27, 2025, that its fourth Phase III clinical…<\/p>\n","protected":false},"author":1,"featured_media":44598,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[7,11],"tags":[17,910,198,86],"class_list":["post-44597","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-company","category-drug","tag-clinical-trial-results","tag-hkg-1801","tag-innovent-biologics","tag-obesity"],"yoast_head":"\nInnovent's Mazdutide Meets Phase III Endpoint in Type 2 Diabetes and Obesity Trial - Insight, China's Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"Innovent Biologics (HKG: 1801) announced on October 27, 2025, that its fourth Phase III clinical study (DREAMS-3) for Mazdutide (IBI362), a Glucagon (GCG)\/Glucagon-like Peptide-1 (GLP-1) dual receptor agonist, has met its primary endpoint.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/flcube.com\/?p=44597\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Innovent's Mazdutide Meets Phase III Endpoint in Type 2 Diabetes and Obesity Trial\" \/>\n<meta property=\"og:description\" content=\"Innovent Biologics (HKG: 1801) announced on October 27, 2025, that its fourth Phase III clinical study (DREAMS-3) for Mazdutide (IBI362), a Glucagon (GCG)\/Glucagon-like Peptide-1 (GLP-1) dual receptor agonist, has met its primary endpoint.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/flcube.com\/?p=44597\" \/>\n<meta property=\"og:site_name\" content=\"Insight, China's Pharmaceutical Industry\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/profile.php?id=61566606313834\" \/>\n<meta property=\"article:published_time\" content=\"2025-10-27T14:03:04+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-10-27T14:03:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/flcube.com\/wp-content\/uploads\/2025\/10\/2707.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1080\" \/>\n\t<meta property=\"og:image:height\" content=\"608\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Fineline Cube\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:description\" content=\"Navigate the complexities of China\u2019s pharmaceutical industry with precision and clarity. 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