{"id":45265,"date":"2025-10-30T15:39:54","date_gmt":"2025-10-30T07:39:54","guid":{"rendered":"https:\/\/flcube.com\/?p=45265"},"modified":"2025-10-30T15:39:55","modified_gmt":"2025-10-30T07:39:55","slug":"innocare-announces-first-patient-dosing-of-icp%e2%80%91b794-a-novel-b7%e2%80%91h3-targeting-adc","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=45265","title":{"rendered":"InnoCare Announces First Patient Dosing of ICP\u2011B794, a Novel B7\u2011H3 Targeting ADC"},"content":{"rendered":"\n<p><strong>China\u2011based InnoCare Pharma Limited<\/strong> (<a href=\"https:\/\/www.google.com\/finance\/quote\/688428:SHA\">SHA: 688428<\/a>, <a href=\"https:\/\/www.google.com\/finance\/quote\/9969:HKG\">HKG: 9969<\/a>) today disclosed that its self\u2011developed antibody\u2011drug conjugate (ADC) <strong>ICP\u2011B794<\/strong>, which targets the tumor\u2011associated antigen <strong>B7\u2011H3<\/strong>, has successfully completed the first patient dose in its ongoing clinical trial.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-how-icp-b794-works\"><strong>How ICP\u2011B794 Works<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Design<\/strong> \u2013 ICP\u2011B794 couples a humanized anti\u2011B7\u2011H3 monoclonal antibody to a potent cytotoxic payload via a protease\u2011cleavable linker.<\/li>\n\n\n\n<li><strong>Target Specificity<\/strong> \u2013 The linker strategy is engineered to release the drug only within the tumor microenvironment, thereby minimizing off\u2011target toxicity.<\/li>\n\n\n\n<li><strong>Clinical Potential<\/strong> \u2013 The ADC is intended for solid\u2011tumor indications, including lung, esophageal, nasopharyngeal, head\u2011and\u2011neck squamous cell, and prostate cancers.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-preclinical-promise\"><strong>Preclinical Promise<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>In murine models, ICP\u2011B794 outperformed existing B7\u2011H3\u2011directed agents, demonstrating robust tumor\u2011kill activity even against sizable lesions.<\/li>\n\n\n\n<li>No B7\u2011H3\u2011targeted therapies have yet gained regulatory approval worldwide, underscoring the significance of InnoCare\u2019s platform.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-next-milestones\"><strong>Next Milestones<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Phase\u202fI Expansion<\/strong> \u2013 Following the first\u2011dose cohort, InnoCare will enroll additional patients to evaluate safety, tolerability, and preliminary efficacy.<\/li>\n\n\n\n<li><strong>Biomarker Development<\/strong> \u2013 Companion diagnostics for B7\u2011H3 expression will be refined to identify optimal patient populations.<\/li>\n<\/ul>\n\n\n\n<p><strong>Forward\u2011Looking Statements<\/strong><br>This release contains forward\u2011looking statements that involve risks and uncertainties. Actual results may differ materially.<a href=\"https:\/\/flcube.com\/\">-Fineline Info &amp; Tech<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>China\u2011based InnoCare Pharma Limited (SHA: 688428, HKG: 9969) today disclosed that its self\u2011developed antibody\u2011drug conjugate&#8230;<\/p>\n","protected":false},"author":1,"featured_media":45267,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[7,11],"tags":[35,62,919,327,920],"class_list":["post-45265","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-company","category-drug","tag-adc-xdc","tag-clinical-trial-approval-initiation","tag-hkg-9969","tag-innocare-pharma","tag-sha-688428"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v27.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>InnoCare Announces First Patient Dosing of ICP\u2011B794, a Novel B7\u2011H3 Targeting ADC - Insight, China&#039;s Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"China\u2011based InnoCare Pharma Limited (SHA: 688428, HKG: 9969) today disclosed that its self\u2011developed antibody\u2011drug conjugate (ADC) ICP\u2011B794, which targets the tumor\u2011associated antigen B7\u2011H3, has successfully completed the first patient dose in its ongoing clinical trial.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/flcube.com\/?p=45265\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"InnoCare Announces First Patient Dosing of ICP\u2011B794, a Novel B7\u2011H3 Targeting ADC\" \/>\n<meta property=\"og:description\" content=\"China\u2011based InnoCare Pharma Limited (SHA: 688428, HKG: 9969) today disclosed that its self\u2011developed antibody\u2011drug conjugate (ADC) ICP\u2011B794, which targets the tumor\u2011associated antigen B7\u2011H3, has successfully completed the first patient dose in its ongoing clinical trial.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/flcube.com\/?p=45265\" \/>\n<meta property=\"og:site_name\" content=\"Insight, China&#039;s Pharmaceutical Industry\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/profile.php?id=61566606313834\" \/>\n<meta property=\"article:published_time\" content=\"2025-10-30T07:39:54+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-10-30T07:39:55+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/flcube.com\/wp-content\/uploads\/2025\/10\/3003.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1080\" \/>\n\t<meta property=\"og:image:height\" content=\"608\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Fineline Cube\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:description\" content=\"Navigate the complexities of China\u2019s pharmaceutical industry with precision and clarity. 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