{"id":72332,"date":"2026-08-12T11:28:38","date_gmt":"2026-08-12T03:28:38","guid":{"rendered":"https:\/\/flcube.com\/?p=72332"},"modified":"2026-08-12T11:28:38","modified_gmt":"2026-08-12T03:28:38","slug":"tempest-therapeutics-signs-strategic-partnership-with-senlang-to-advance-tpst-4003-in-vivo-car-t-candidate-in-china","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=72332","title":{"rendered":"Tempest Therapeutics Signs Strategic Partnership With Senlang to Advance TPST\u20114003 In Vivo CAR\u2011T Candidate in China"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Tempest Therapeutics, Inc.<\/strong> (<a href=\"https:\/\/www.google.com\/finance\/beta\/quote\/TPST:NASDAQ\">NASDAQ: TPST<\/a>) announced a <strong>strategic partnership<\/strong> with <strong>Hebei Senlang Biotechnology Co., Ltd.<\/strong> (&#8220;Senlang&#8221;) to co\u2011develop Tempest&#8217;s proprietary <strong>TPST\u20114003<\/strong> product candidate. The collaboration will begin with an <strong>investigator\u2011initiated trial (&#8220;IIT&#8221;)<\/strong> in China evaluating TPST\u20114003 in approximately <strong>10 patients<\/strong> with <strong>myasthenia gravis (&#8220;MG&#8221;)<\/strong> or <strong>multiple sclerosis (&#8220;MS&#8221;)<\/strong>. Tempest expects <strong>first patient enrollment and dosing in the fourth quarter of 2026<\/strong>.<\/p>\n\n\n\n<h2 id=\"h-deal-overview\" class=\"wp-block-heading\">Deal Overview<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Item<\/th><th>Detail<\/th><\/tr><\/thead><tbody><tr><td><strong>Companies<\/strong><\/td><td>Tempest Therapeutics, Inc. (NASDAQ: TPST) \/ Hebei Senlang Biotechnology Co., Ltd.<\/td><\/tr><tr><td><strong>Agreement Type<\/strong><\/td><td>Strategic development partnership<\/td><\/tr><tr><td><strong>Asset<\/strong><\/td><td>TPST\u20114003 (next\u2011generation in vivo CAR\u2011T candidate)<\/td><\/tr><tr><td><strong>Initial Study<\/strong><\/td><td>Investigator\u2011initiated trial (IIT) in China<\/td><\/tr><tr><td><strong>Patient Population<\/strong><\/td><td>~10 patients with myasthenia gravis (MG) or multiple sclerosis (MS)<\/td><\/tr><tr><td><strong>Timeline<\/strong><\/td><td>First enrollment and dosing expected Q4 2026<\/td><\/tr><tr><td><strong>China Option<\/strong><\/td><td>Senlang granted exclusive option to negotiate a definitive license for TPST\u20114003 in China<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 id=\"h-drug-profile-amp-mechanism\" class=\"wp-block-heading\">Drug Profile &amp; Mechanism<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Modality:<\/strong> Next\u2011generation <strong>in vivo CAR\u2011T<\/strong> candidate (no ex vivo cell manufacturing required).<\/li>\n\n\n\n<li><strong>Delivery:<\/strong> Proprietary <strong>CD7\u2011targeted mRNA\/LNP<\/strong> delivery platform.<\/li>\n\n\n\n<li><strong>CAR Construct:<\/strong> <strong>Dual\u2011target CD19\/BCMA<\/strong> design for broad <strong>B\u2011cell lineage depletion<\/strong> and <strong>immune reset<\/strong>.<\/li>\n\n\n\n<li><strong>Intended Indications:<\/strong> <strong>Autoimmune<\/strong> and <strong>oncology<\/strong> applications.<\/li>\n\n\n\n<li><strong>Study Goal:<\/strong> Initial trial designed to generate clinical evidence of <strong>safety<\/strong>, <strong>pharmacodynamic (&#8220;PD&#8221;) activity<\/strong>, and <strong>therapeutic potential<\/strong>.<\/li>\n<\/ul>\n\n\n\n<h2 id=\"h-strategic-rationale\" class=\"wp-block-heading\">Strategic Rationale<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Senlang Execution Role:<\/strong> Under the agreement, <strong>Senlang will coordinate and support trial execution in China<\/strong>, leveraging its extensive experience in the clinical development of advanced CAR\u2011T therapies.<\/li>\n\n\n\n<li><strong>Exclusive Licensing Option:<\/strong> The agreement grants <strong>Senlang an exclusive option to negotiate and enter into a definitive license agreement<\/strong> for TPST\u20114003 in China, establishing a potential regional commercial pathway.<\/li>\n\n\n\n<li><strong>Platform Validation:<\/strong> The IIT is positioned as a first clinical read\u2011out for Tempest&#8217;s in vivo CAR\u2011T delivery platform, a modality that could streamline CAR\u2011T access by avoiding bespoke cell manufacturing.<\/li>\n<\/ul>\n\n\n\n<h2 id=\"h-market-impact-amp-outlook\" class=\"wp-block-heading\">Market Impact &amp; Outlook<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>In Vivo CAR\u2011T Race:<\/strong> Off\u2011the\u2011shelf, in vivo CAR\u2011T approaches are attracting significant investor interest for their potential to broaden CAR\u2011T use into autoimmune disease, a far larger market than oncology alone.<\/li>\n\n\n\n<li><strong>Autoimmune Addressable Need:<\/strong> MG and MS are chronic immune\u2011mediated diseases with significant unmet need, where a B\u2011cell depletion and immune\u2011reset strategy could offer durable treatment responses.<\/li>\n\n\n\n<li><strong>Regional Strategy:<\/strong> Pairing Tempest&#8217;s platform with Senlang&#8217;s China clinical expertise accelerates regional development while preserving Tempest&#8217;s global rights pending any China license outcome.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Forward\u2011Looking Statements<\/strong><br>This brief contains forward\u2011looking statements regarding trial timing, clinical outcomes, and licensing discussions for TPST\u20114003. Actual results may differ due to risks including regulatory approvals, enrollment, clinical response, and definitive agreement terms.<a href=\"https:\/\/flcube.com\/\">-Fineline Info &amp; Tech<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tempest Therapeutics, Inc. (NASDAQ: TPST) announced a strategic partnership with Hebei Senlang Biotechnology Co., Ltd&#8230;.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[7,10],"tags":[21,77,4888,4267,4887],"class_list":["post-72332","post","type-post","status-publish","format-standard","hentry","category-company","category-deals","tag-car-t","tag-cell-therapy","tag-nasdaq-tpst","tag-senlang-biotechnology","tag-tempest-therapeutics"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.5 (Yoast SEO v28.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Tempest Therapeutics Signs Strategic Partnership With Senlang to Advance TPST\u20114003 In Vivo CAR\u2011T Candidate in China - Insight, China&#039;s Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"Tempest Therapeutics, Inc. (NASDAQ: TPST) announced a strategic partnership with Hebei Senlang Biotechnology Co., Ltd. (&quot;Senlang&quot;) to co\u2011develop Tempest&#039;s proprietary TPST\u20114003 product candidate. The collaboration will begin with an investigator\u2011initiated trial (&quot;IIT&quot;) in China evaluating TPST\u20114003 in approximately 10 patients with myasthenia gravis (&quot;MG&quot;) or multiple sclerosis (&quot;MS&quot;). 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