{"id":78181,"date":"2026-09-02T15:21:59","date_gmt":"2026-09-02T07:21:59","guid":{"rendered":"https:\/\/flcube.com\/?p=78181"},"modified":"2026-09-02T15:22:00","modified_gmt":"2026-09-02T07:22:00","slug":"allergan-aesthetics-skinvive-by-juvederm-wins-nmpa-approval-for-perioral-wrinkles-backed-by-93-4-polss-responder-rate","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=78181","title":{"rendered":"Allergan Aesthetics&#8217; SKINVIVE by Juv\u00e9derm Wins NMPA Approval for Perioral Wrinkles, Backed by 93.4% POLSS Responder Rate"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Allergan Aesthetics<\/strong>, an <strong>AbbVie<\/strong> (<a href=\"https:\/\/www.google.com\/finance\/beta\/quote\/ABBV:NYSE\">NYSE: ABBV<\/a>) company, announced that its <strong>SKINVIVE by Juv\u00e9derm<\/strong>, an injectable hyaluronic acid gel with lidocaine, has received marketing approval from China&#8217;s <strong>National Medical Products Administration (NMPA)<\/strong> for the improvement of moderate-to-severe static perioral wrinkles in adults.<\/p>\n\n\n\n<h2 id=\"h-regulatory-milestone\" class=\"wp-block-heading\">Regulatory Milestone<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Agency<\/th><th>Approval Type<\/th><th>Product<\/th><th>Indication<\/th><th>Date<\/th><th>Next Steps<\/th><\/tr><\/thead><tbody><tr><td><strong>NMPA<\/strong> (China)<\/td><td>Marketing Approval<\/td><td><strong>SKINVIVE by Juv\u00e9derm<\/strong> (injectable hyaluronic acid gel with lidocaine)<\/td><td>Improvement of moderate-to-severe static perioral wrinkles in adults<\/td><td>02 Sep 2026<\/td><td>Commercial launch in China&#8217;s medical aesthetics market<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 id=\"h-drug-profile-amp-mechanism-of-action\" class=\"wp-block-heading\">Drug Profile &amp; Mechanism of Action<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Product:<\/strong> SKINVIVE by Juv\u00e9derm, an injectable hyaluronic acid (HA) gel with lidocaine<\/li>\n\n\n\n<li><strong>Technology:<\/strong> Developed using <strong>Allergan Aesthetics<\/strong>&#8216; proprietary <strong>VYCROSS<\/strong> cross-linking technology<\/li>\n\n\n\n<li><strong>Formulation characteristics:<\/strong> Soft texture and low cohesiveness, well-suited to the frequently mobile skin environment of the perioral area<\/li>\n\n\n\n<li><strong>Target area:<\/strong> Static perioral wrinkles \u2014 a high-motion facial region where product flexibility matters<\/li>\n\n\n\n<li><strong>Owner:<\/strong> <strong>Allergan Aesthetics<\/strong>, part of <strong>AbbVie<\/strong>, extending the established <strong>Juv\u00e9derm<\/strong> franchise in China<\/li>\n<\/ul>\n\n\n\n<h2 id=\"h-clinical-evidence-phase-3-china-registration-trial\" class=\"wp-block-heading\">Clinical Evidence \u2013 Phase 3 China Registration Trial<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Endpoint<\/th><th>Timepoint<\/th><th>Treatment Group Result<\/th><\/tr><\/thead><tbody><tr><td>POLSS responder rate (primary, investigator-assessed on-site)<\/td><td>2 months post-treatment<\/td><td><strong>93.4%<\/strong><\/td><\/tr><tr><td>POLSS responder rate (durability follow-up)<\/td><td>6 months post-treatment<\/td><td><strong>89.2%<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">The approval is supported by a multicenter, evaluator-blinded, randomized, no-treatment controlled Phase 3 trial conducted in a Chinese population, using the Perioral Wrinkle Static Severity Scale (POLSS) responder rate as the primary efficacy endpoint. Results demonstrated that a single treatment session can deliver durable results for at least 6 months, with the responder rate holding at 89.2% at the 6-month follow-up.<\/p>\n\n\n\n<h2 id=\"h-market-impact-amp-outlook\" class=\"wp-block-heading\">Market Impact &amp; Outlook<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>China aesthetics expansion:<\/strong> The <strong>NMPA<\/strong> approval broadens the <strong>Juv\u00e9derm<\/strong> portfolio in China, one of the world&#8217;s largest and fastest-growing medical aesthetics markets<\/li>\n\n\n\n<li><strong>Indication positioning:<\/strong> Moderate-to-severe static perioral wrinkles represent a distinct treatment niche versus volumizing fillers, expanding the addressable patient base for <strong>SKINVIVE<\/strong><\/li>\n\n\n\n<li><strong>Clinical differentiation:<\/strong> A 93.4% POLSS responder rate at 2 months with durability beyond 6 months from a single session provides a strong efficacy narrative for clinicians and consumers<\/li>\n\n\n\n<li><strong>Technology edge:<\/strong> The <strong>VYCROSS<\/strong> platform&#8217;s soft, low-cohesiveness profile addresses the unique biomechanical demands of the perioral area<\/li>\n\n\n\n<li><strong>Sector signal:<\/strong> The approval underscores continued investment by global aesthetics leaders in China-specific registration studies and local market penetration<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Forward\u2011Looking Statements<\/strong> \u2013 This brief contains forward-looking statements regarding the commercialization and market potential of SKINVIVE by Juv\u00e9derm in China. Actual results may differ materially due to regulatory, competitive, and market risks. This content is for informational purposes only and does not constitute investment advice.<a href=\"https:\/\/flcube.com\/\">-Fineline Info &amp; Tech<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Allergan Aesthetics, an AbbVie (NYSE: ABBV) company, announced that its SKINVIVE by Juv\u00e9derm, an injectable&#8230;<\/p>\n","protected":false},"author":1,"featured_media":78183,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[7,11,4908],"tags":[234,435,100,853,15],"class_list":["post-78181","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-company","category-drug","category-pic","tag-abbvie","tag-allergan-aesthetics","tag-medical-aesthetics","tag-nyse-abbv","tag-product-approvals"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.5 (Yoast SEO v28.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Allergan Aesthetics&#039; SKINVIVE by Juv\u00e9derm Wins NMPA Approval for Perioral Wrinkles, Backed by 93.4% POLSS Responder Rate - Insight, China&#039;s Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"Allergan Aesthetics, an AbbVie (NYSE: ABBV) company, announced that its SKINVIVE by Juv\u00e9derm, an injectable hyaluronic acid gel with lidocaine, has received marketing approval from China&#039;s National Medical Products Administration (NMPA) for the improvement of moderate-to-severe static perioral wrinkles in adults.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/flcube.com\/?p=78181\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Allergan Aesthetics&#039; SKINVIVE by Juv\u00e9derm Wins NMPA Approval for Perioral Wrinkles, Backed by 93.4% POLSS Responder Rate\" \/>\n<meta property=\"og:description\" content=\"Allergan Aesthetics, an AbbVie (NYSE: ABBV) company, announced that its SKINVIVE by Juv\u00e9derm, an injectable hyaluronic acid gel with lidocaine, has received marketing approval from China&#039;s National Medical Products Administration (NMPA) for the improvement of moderate-to-severe static perioral wrinkles in adults.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/flcube.com\/?p=78181\" \/>\n<meta property=\"og:site_name\" content=\"Insight, China&#039;s Pharmaceutical Industry\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/profile.php?id=61566606313834\" \/>\n<meta property=\"article:published_time\" content=\"2026-09-02T07:21:59+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-09-02T07:22:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/flcube.com\/wp-content\/uploads\/2026\/09\/0202.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1080\" \/>\n\t<meta property=\"og:image:height\" content=\"608\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Fineline Cube\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:description\" content=\"Navigate the complexities of China\u2019s pharmaceutical industry with precision and clarity. 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