{"id":9604,"date":"2024-01-25T13:49:00","date_gmt":"2024-01-25T05:49:00","guid":{"rendered":"https:\/\/flcube.com\/?p=9604"},"modified":"2024-10-26T13:53:09","modified_gmt":"2024-10-26T05:53:09","slug":"phanes-therapeutics-first-in-class-bsab-pt217-accepted-for-review-by-chinas-cde","status":"publish","type":"post","link":"https:\/\/flcube.com\/?p=9604","title":{"rendered":"Phanes Therapeutics&#8217; First-in-Class BsAb PT217 Accepted for Review by China&#8217;s CDE"},"content":{"rendered":"\n<p>Sino-US biotechnology company Phanes Therapeutics Inc. has announced that the Investigational New Drug (IND) filing for its potential first-in-class in-house bispecific antibody (BsAb) PT217 has been accepted for review by China&#8217;s Center for Drug Evaluation (CDE). PT217 is designed to directly kill tumor cells through the antibody-dependent cellular phagocytosis (ADCP) activity of macrophages and the antibody-dependent cellular cytotoxicity (ADCC) activity of natural killer (NK) cells. It targets the overexpressed DLL3 and CD47 on the surface of tumor cells, expanding the range of tumor killing.<\/p>\n\n\n\n<p>Additionally, PT217 is anticipated to induce the presentation of tumor neoantigens by guiding tumor cells into phagocytic antigen-presenting cells (APCs), indirectly activating T cells to kill tumor cells with low or no DLL3 expression by recognizing tumor neoantigens, thus stimulating the acquired immune system. The anti-CD47 component of PT217 has shown high differentiation in preclinical models, maintaining strong binding activity with CD47 on tumor cells while minimizing binding to human red blood cells.<\/p>\n\n\n\n<p>PT217 received clearance for a Phase I study in the US in 2022 and was awarded Orphan Drug Designation (ODD) status for the treatment of small-cell lung cancer by the US FDA the same year.- <a href=\"https:\/\/flcube.com\">Flcube.com<\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sino-US biotechnology company Phanes Therapeutics Inc. has announced that the Investigational New Drug (IND) filing&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAownpewDA:productID":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[7,11],"tags":[16,90,28,1517,25],"class_list":["post-9604","post","type-post","status-publish","format-standard","hentry","category-company","category-drug","tag-cancer","tag-clinical-trial-filings","tag-multi-specific-antibodies","tag-phanes-therapeutics","tag-potential-first-in-class"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v27.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Phanes Therapeutics&#039; First-in-Class BsAb PT217 Accepted for Review by China&#039;s CDE - Insight, China&#039;s Pharmaceutical Industry<\/title>\n<meta name=\"description\" content=\"Sino-US biotechnology company Phanes Therapeutics Inc. has announced that the Investigational New Drug (IND) filing for its potential first-in-class in-house bispecific antibody (BsAb) PT217 has been accepted for review by China&#039;s Center for Drug Evaluation (CDE). PT217 is designed to directly kill tumor cells through the antibody-dependent cellular phagocytosis (ADCP) activity of macrophages and the antibody-dependent cellular cytotoxicity (ADCC) activity of natural killer (NK) cells. It targets the overexpressed DLL3 and CD47 on the surface of tumor cells, expanding the range of tumor killing.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/flcube.com\/?p=9604\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Phanes Therapeutics&#039; First-in-Class BsAb PT217 Accepted for Review by China&#039;s CDE\" \/>\n<meta property=\"og:description\" content=\"Navigate the complexities of China\u2019s pharmaceutical industry with precision and clarity. 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