China-based Simcere Pharmaceutical Group (HKG: 2096) has announced a strategic collaboration agreement with domestic firm AnDiCon Bio. The collaboration centers on AnDiCon’s pipeline candidate, ADC189, with Simcere now holding exclusive commercialization rights for the drug in China.
ADC189: A Novel Anti-Influenza Treatment
ADC189 is an innovative anti-influenza polymerase acidic protein (PA) inhibitor that directly targets the replication of influenza viruses. It combats both influenza A and B by inhibiting CAP cap dependent endonuclease (CEN) in the viruses. Preclinical studies have demonstrated several advantages of ADC189, including the absence of central nervous system side effects, oral absorption that is not affected by food, and a higher safe dosage threshold.
Efficiency and Convenience of ADC189
A significant benefit of ADC189 is its convenience compared to existing treatments. While oseltamivir requires a 5-day continuous administration, ADC189 can achieve its effect with a single oral dose, potentially preventing influenza virus replication within 24 hours.
Simcere’s Expanding Anti-Infective Portfolio
In the anti-infective field, Simcere is known for developing China’s first home-grown oral COVID-19 drug, Xiannuoxin (simnotrelvir, ritonavir). The addition of ADC189 to their portfolio further diversifies their offerings and strengthens their position in the anti-infective market.
Conclusion
The collaboration between Simcere Pharmaceutical and AnDiCon Bio marks a significant step forward in the development and commercialization of novel anti-infective drugs in China. With the exclusive rights to ADC189, Simcere is poised to bring a new and effective treatment option to patients suffering from influenza.-Fineline Info & Tech