China-based Everest Medicines (HKG: 1952) has announced that its Investigational New Drug (IND) application for EVM14, a tumor-associated antigen (TAA) vaccine, has been cleared by the US Food and Drug Administration (FDA). This milestone marks a significant advancement for the company’s innovative oncology pipeline.
EVM14’s Mechanism and Pre-Clinical Success
EVM14 is a universal off-the-shelf mRNA cancer vaccine designed to treat various cancers. In pre-clinical studies, it demonstrated a dose-dependent antigen-specific immune response in mice and significantly inhibited tumor growth in multiple syngeneic tumor models. These results highlight its potential as a versatile therapeutic option across different cancer types.
Synergistic Potential with Immune Checkpoint Inhibitors
The drug candidate is expected to deliver enhanced anti-tumor activity when combined with immune checkpoint inhibitors. This synergistic potential positions EVM14 as a promising addition to existing cancer treatment regimens, potentially improving outcomes for patients with diverse tumor profiles.-Fineline Info & Tech
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