China’s genomics giant BGI has revealed a landmark study using its proprietary Stereo-seq sequencing technology to construct the world’s first spatiotemporal cellular atlas of brain development and regeneration in axolotls, a species of salamander. The research, featured on the front cover of the latest Science issue, sheds light on vertebrate brain regeneration mechanisms and holds implications for regenerative medicine.
Study Breakthroughs
The multi-institute team, led by BGI-Research, applied spatial enhanced resolution omics sequencing (Stereo-seq) to map single-cell transcriptomes in axolotl telencephalon sections during development and regeneration. The study identified key neural stem cell subsets driving regeneration and found parallels between regenerative and developmental processes. These insights could aid in reconstructing damaged neurons and advancing nervous system treatments.
Research Impact
Dr. Ying Gu, a joint corresponding author, stated: “Using axolotls as a model, we pinpointed critical cell types in brain regeneration. This discovery offers new directions for regenerative medicine in mammals.” Collaborators included institutions such as Wuhan University, the Chinese Academy of Sciences, and the University of Copenhagen.-Fineline Info & Tech
