Researchers at The University of Hong Kong’s Li Ka Shing Faculty of Medicine (HKUMed) and City University of Hong Kong (CityU) have conducted two preclinical studies demonstrating the therapeutic potential of transcorneal electrical stimulation (TES) in treating depression and Alzheimer’s disease. The findings suggest that TES, a minimally invasive approach, could offer a non-invasive treatment option for neuro-psychiatric and neurodegenerative disorders.
Study Highlights
- Depression Study: TES produced antidepressant-like effects in rat models by normalizing plasma corticosterone and modulating neuroplasticity in the hippocampus and amygdala.
- Alzheimer’s Study: TES improved cognitive function and reduced beta-amyloid plaque levels in aged and 5XFAD mouse models.
Mechanisms and Future Directions
The researchers hypothesize that TES achieves its effects through the normalization of stress hormones and enhancement of neuroplasticity. Given the extensive interconnections between the visual and emotional systems, TES could potentially influence limbic regions like the hippocampus and amygdala. The studies, led by Yu Wing Shan, were published in Annals of the New York Academy of Sciences and Brain Stimulation. Future work may explore clinical trials to validate TES as a therapeutic option.-Fineline Info & Tech
