Everest Medicines Revenue Surges 142% to RMB 1.7B – Nefecon Becomes First Non-Oncology Drug to Hit RMB 1B in First NRDL Year

Everest Medicines Revenue Surges 142% to RMB 1.7B – Nefecon Becomes First Non-Oncology Drug to Hit RMB 1B in First NRDL Year

Everest Medicines (HKG: 1952) reported 2024 financial results, with revenue skyrocketing 142% YoY to RMB 1.707 billion (USD 247 million) driven by Nefecon (budesonide delayed-release capsules) rapid commercial uptake. The world’s first etiological treatment for IgA nephropathy became the first non-oncology drug to exceed RMB 1 billion revenue within its first year of NRDL inclusion (January 2025). Non-IFRS net loss narrowed 71% to RMB 298 million, with strong cash balance of RMB 2.731 billion (USD 395 million) supporting pipeline advancement.

Financial Highlights

Metric2024 ResultYoY ChangeStrategic Driver
Total RevenueRMB 1.707 billion (USD 247M)+142%Nefecon NRDL inclusion + rapid market penetration
Non-IFRS Net LossRMB 298 million (USD 43.2M)-71% (narrowed)Operating leverage from commercial scale
Cash BalanceRMB 2.731 billion (USD 395M)Strong3+ years runway for pipeline execution
Nefecon Revenue>RMB 1 billion (USD 144M+)First-year NRDL recordFirst non-oncology drug to achieve milestone in debut NRDL year

Commercial Success: Nefecon (IgA Nephropathy)

AchievementSignificance
World’s First Etiological TreatmentAddresses root cause of IgA nephropathy (gut mucosal immunity) vs. symptomatic management
NRDL InclusionJanuary 2025 – national reimbursement unlocks volume access
Revenue Milestone>RMB 1 billion in first NRDL year – unprecedented for non-oncology innovative drug in China
Market PositionCategory leader in IgA nephropathy; ~500,000 diagnosed patients in China with high unmet need

Clinical Pipeline Progress

AssetIndication2024/2025 Milestone2026 Catalyst
EVER001Membranous nephropathy (MN)Positive Ib/IIa dataPhase II basket trial (H1 2026) – IgA nephropathy, FSGS, MCD
VIS-101Wet AMDPositive Phase IIa toplineNext-phase advancement (2026) – novel bifunctional biologic
LEROCHOL (PCSK9 inhibitor)HypercholesterolemiaLicensed from LIB TherapeuticsGreater China NDA filing (H1 2026)
Cardamyst (etripamil)Paroxysmal SVT (PSVT)Licensed from CardionovumChina approval expected (Q3 2026)

Strategic Context: Diversified Portfolio

Therapeutic AreaAssetsRevenue/Regulatory Trajectory
NephrologyNefecon (approved), EVER001 (Phase II)Nefecon blockbuster trajectory; EVER001 basket trial expands addressable market 3x
OphthalmologyVIS-101 (Phase II)Bifunctional biologic differentiation in $3B+ China wAMD market
CardiometabolicLEROCHOL (NDA-ready), Cardamyst (approval pending)2026 revenue diversification beyond nephrology; PCSK9 + antiarrhythmic synergy

Forward‑Looking Statements
This brief contains forward‑looking statements regarding 2026 clinical trial initiations, NDA filings, and regulatory approvals for EVER001, VIS-101, LEROCHOL, and Cardamyst. Actual results may differ due to clinical efficacy outcomes, competitive dynamics in IgA nephropathy (sparsentan, iptacopan), and reimbursement negotiations for pipeline assets.-Fineline Info & Tech