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Biosion and ImmunoGen Collaborate on Cancer ADCs
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China-based Biosion Inc. announced an exploratory research collaboration to create antibody-drug conjugates (ADCs) for the treatment of cancer with US firm ImmunoGen, Inc. (Nasdaq: IMGN). Biosion will leverage its proprietary SynTracer high-throughput (HT) endocytosis platform to generate highly selective antibodies to targets allocated by each company, and ImmunoGen will provide…
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Abcam and Wuxi Diagnostics Expand Partnership into Companion Diagnostics
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UK-headquartered Abcam plc. and China-based Wuxi Diagnostics have expanded their partnership to dive deep into the companion diagnostics (CDx) field. No financial details were disclosed. Abcam’s Role in Life Science ResearchAbcam is a global life science company supporting customers at the forefront of life science research, and is engaged in…
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Ascentage Pharma’s APG-2575 Shows Promising Results in Global Phase II Study
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Suzhou-based Ascentage Pharma (HKG: 6855) unveiled preliminary data from the global Phase II clinical study for its APG-2575, alone or combined with Calquence (acalabrutinib) plus rituximab, in recurrent/refractory (R/R) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The results were released at the 64th American Society of Hematology (ASH) annual meeting this…
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ImmuneOnco’s IMM2520 Receives FDA Clinical Trial Approval
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ImmuneOnco Biopharmaceuticals (Shanghai) Co., Ltd announced receiving clinical trial approval from the US FDA for its IMM2520, a bispecific antibody (BsAb) targeting CD47 and PD-L1 in solid tumors. Mechanism of Action and Preclinical ResultsIMM2520, featuring functional IgG1 Fc, can activate macrophages and T cells simultaneously by targeting CD47 and PD-L1…
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Treadwell Therapeutics Presents PLK4 Inhibitor Data at ASH Annual Meeting
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China-based Treadwell Therapeutics presented results of the company’s CFI-400945 program, a first-in-class inhibitor of Polo-like Kinase 4 (PLK4), a critical regulator of centriole duplication, at the 64th American Society of Hematology (ASH) annual meeting. The poster presentation described the preliminary results from the monotherapy dose optimization portion of the TWT-202…
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Asieris Pharmaceuticals Enrolls First Patient in Phase II Study for APL-1202
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China-based Asieris Pharmaceuticals (SHA: 688176) announced the first patient enrollment in a Phase II clinical study for its oral drug candidate APL-1202 in combination with the PD-1 inhibitor tislelizumab as a neoadjuvant therapy for muscular invasive bladder cancer (MIBC). The open-label, multi-center Phase I/II clinical study is designed to evaluate…
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Angel Pharmaceuticals Presents CPI-818 Data at ASH 2022 Annual Meeting
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China-based Angel Pharmaceuticals Ltd announced the latest results of the global Phase I/Ib clinical study for CPI-818, a first-in-class ITK inhibitor co-developed by US partner Corvus Pharmaceuticals, at the American Society of Hematology (ASH) 2022 annual meeting. The study has shown the anti-tumor activities in T-cell lymphoma (TCL), alongside therapeutic…
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Wuhan YZY Biopharma Files for IPO on Hong Kong Stock Exchange
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China-based Wuhan YZY Biopharma Co., Ltd, a biopharmaceutical company focused on targeted cancer drugs and drug immunotherapies, has made an initial public offering (IPO) filing to the Hong Kong Stock Exchange. Product Pipeline and R&D FocusYZY Bio, focused on the research and development (R&D) and industrialization of bispecific antibodies (BsAb),…
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JW Therapeutics Presents Carteyva Data at ASH Annual Meeting
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China-based JW Therapeutics (HKG: 2126) presented the latest clinical data on Carteyva (relmacabtagene autoleucel injection) in Chinese adults with relapsed/refractory follicular lymphoma (r/r FL) and relapsed/refractory mantle cell lymphoma (r/r MCL) at the 64th American Society of Hematology (ASH) annual meeting. Efficacy and Safety in Relapsed/Refractory Follicular LymphomaIn the pivotal…
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Dizal Pharma Presents Golidocitinib Data at ASH Annual Meeting
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China-based Dizal Pharmaceutical Co., Ltd (SHA: 688192) presented the latest clinical data on golidocitinib (DZD4205) at the 64th American Society of Hematology (ASH) annual meeting. Global Multi-Center Phase I/II StudyA global multi-center Phase I/II study for golidocitinib in recurrent refractory peripheral T-cell lymphoma (r/r PTCL) included a total of 51…
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Sino Biopharmaceutical’s ATR Kinase Inhibitor TCC1727 Accepted for FDA Review
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China-based Sino Biopharmaceutical Ltd (HKG: 1177) announced the acceptance for review of its Investigational New Drug (IND) filing for its in-house developed selective ATR kinase inhibitor TCC1727 by the US FDA. ATR Kinase and TCC1727 MechanismATR, namely ataxia telangiectasia and Rad-3-related protein, is a family of protein serine/threonine kinases and…
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Medbanks Set for IPO on Hong Kong Stock Exchange
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Sipai Health Technology Co., Ltd, also known as Medbanks, is set to make an initial public offering (IPO) of 9.92 million shares to the Hong Kong Stock Exchange (HKSE), priced at HKD 18.6 (USD 2.39) per share. The online health platform expects to take home HKD 184 million (USD 23.66…
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Alphamab Oncology Updates Clinical Studies for KN046 and KN026 at SABCS 2022
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China-based Alphamab Oncology (HKG: 9966) updated the clinical studies for its KN046 and KN026 at the San Antonio Breast Cancer Symposium 2022 annual meeting. KN046/Albumin Paclitaxel in Metastatic TNBCThe Phase II clinical trial is designed to evaluate the efficacy, safety, and tolerability of KN046 combined with albumin paclitaxel in the…
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Roche and Zhongshan Hospital Collaborate on Clinical Studies and Innovation Center
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Swiss giant Roche’s (SWX: ROG) China unit and Roche Diagnostics’ China unit entered into a cooperation memorandum of understanding (MoU) with Shanghai’s Class 3A Zhongshan Hospital, a major teaching hospital affiliated to China’s National Health Commission. The three entities will collaborate on clinical studies in cancer and other diseases, create…
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ASH 2022: China Biotechs Showcase Latest Clinical Trial Results
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The American Society of Hematology (ASH) 2022 annual meeting, held online and offline in New Orleans, Louisiana, USA, saw the latest updates from a string of China-based biotechs. Those included CARsgen Therapeutics Holdings Ltd (HKG: 2171), Gracell Biotechnologies Inc (Nasdaq.GRCL), Innovent Biologics Inc., (HKG: 1801), Junshi Biosciences (HKG: 1877, SHA:…
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RemeGen’s RC118 Receives Orphan Drug Designations for Gastric and Pancreatic Cancers
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China-based RemeGen Ltd announced that its antibody drug conjugate (ADC) drug candidate RC118 has obtained two orphan drug designations (ODD) from the US FDA, for the therapy’s potential use against gastric and pancreatic cancers. RC118: Mechanism and DevelopmentRC118, a novel ADC drug candidate co-developed with contract research organization (CRO) Biocytogen,…
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Innovent Biologics Presents Clinical Study Results at ESMO-IO 2022
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China-based Innovent Biologics Inc. (HKG: 1801) announced the presentation of two clinical studies at the 2022 European Society for Medical Oncology Immuno-Oncology Congress (ESMO-IO). IBI939 Phase Ib Study ResultsA Phase Ib study to evaluate the safety, tolerability, and efficacy of anti-TIGIT candidate IBI939 in combination with sintilimab in patients with…
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Phanes Therapeutics and BeiGene Partner on Phase I Study of PT199
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Sino-US biotech Phanes Therapeutics Inc. announced a clinical study cooperation and supply agreement with China-based biotech BeiGene (HKG: 6160, SHA: 688235, Nasdaq: BGNE) to carry out a Phase I clinical study assessing the safety and efficacy of Phanes’ PT199 combined with BeiGene’s tislelizumab in multiple advanced solid tumors. PT199: Mechanism…
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Harbour BioMed Concludes Phase I Study for HBM4003 in Advanced Melanoma
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Harbour BioMed (HBM; HKG: 2142), a biotech operating out of the United States, the Netherlands, and Suzhou (China), announced the conclusion of a Phase I clinical study for its anti-CTLA-4 antibody HBM4003 combined with Junshi Bio’s programmed death-1 (PD-1) inhibitor Tuoyi (toripalimab) in advanced melanoma. The study has shown that…
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Harbour BioMed’s Nona Biosciences Licenses Antibody Platform to Kelun-Biotech
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Harbour BioMed (HKG: 2142), a biotech operating out of the Netherlands, the United States, and China, announced that its wholly-owned subsidiary Nona Biosciences entered into a licensing agreement with China-based Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Kelun-Biotech will obtain rights to utilize Nona Bio’s proprietary All H2L2 transgenic Harbour Mice platform…
