China-based biopharmaceutical company I-Mab (NASDAQ: IMAB) has announced that its proprietary human granulocyte-macrophage colony-stimulating factor (GM-CSF) neutralizing antibody, plonmarlimab, is poised to receive breakthrough therapy designation (BTD) from the National Medical Products Administration (NMPA) for the treatment of recurrent/refractory hemophagocytic lymphohistiocytosis (R/R MAS), a severe and life-threatening condition. Plonmarlimab is designed to mitigate the hyperactivation of the immune system by targeting the upstream inflammatory cytokine network, potentially reducing severe complications such as lung damage observed in patients with COVID-19. The drug is currently under a Phase II study for MAS, with positive interim results indicating its safety and efficacy. – Flcube.com
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